Figure 3From: Structural equation modeling of factors contributing to quality of life in Japanese patients with multiple sclerosis Causal and mutual relationships with FAMS symptom score. EDSS and knowledge of disease information scores have a direct negative affect on the FAMS symptom score. The standardized total effect of EDSS on FAMS symptom score is -.49, which consists of a standardized direct effect of -.39 and a standardized indirect effect of -.10. Conversely, communication with doctors has a direct positive influence on the FAMS symptom score. Increased scores for changes in employment status and EDSS reduce NAS-J anxiety/depression and acceptance scores, whereas knowledge of disease information scores positively affects these scores. Changes in employment status affect FAMS symptom score indirectly through the NAS-J anxiety/depression and acceptance scores. EDSS and knowledge of disease information scores affects FAMS symptom scores directly and indirectly through the NAS-J anxiety/depression and acceptance scores. d1, e1, e2, and e3 in the figure are error terms. Numbers are standardized path coefficients, and asterisks (*) indicate statistical significance (p < 0.05).Back to article page