Figure 1

Experimental autoimmune encephalomyelitis (EAE) with passive transfer of the NMO-IgG, control IgG and vehicle saline control. (A) EAE scores comparing mice receiving NMO-IgG (diamonds, black line) versus vehicle saline control (squares, grey line) with 4 injections on days 13, 14, 18, and 19 as indicated by the black arrows. EAE scores were statistically different starting from day 15 post-immunization. (B) EAE scores comparing mice receiving the NMO-IgG (diamonds, black line) versus control IgG (circles, black line). EAE scores were statistically different starting from day 25 post-immunization. (C) Weight of NMO-IgG mice (diamonds, black line), control IgG mice (circles, dashed line) and vehicle saline control mice (squares, grey line) during course of EAE. Sample size = 10 mice in the NMO group, 9 in the vehicle contorl group, 5 in the control IgG group. Experiment repeated with similar results.