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Table 1 Summary of findings of intracerebral light chain deposition diseases (No. 1–4) in comparison to intracerebral amyloidomas (No.5)

From: Primary cerebral low-grade B-cell lymphoma, monoclonal immunoglobulin deposition disease, cerebral light chain deposition disease and “aggregoma”: an update on classification and diagnosis

No. and Source 1 2 3 4 5*
Fischer et al. [18] 2006 Popovic et al. [19] 2007 Pantazis et al. [17] 2010 Present case Foreid et al. [16] 2010
Fischer et al. [14] 2007 - (1935–2010) -
Age 19 35 72 61 49 (15–71)
Sex M M M F 13F, 17M
Initial clinical presentation Generalized epileptic seizure A) Progressive Focal epileptic seizure (hemiparesis) Hemiparesis Epileptic seizures (12)
  bulbar palsy
Hemiparesis (6)
B) Putative
Gait disturbance (2)
  Paranoid Visual impairment (4)
  schizophrenia
Cognitive disturbance (5)
Hearing loss (1)
Duration of symptoms No A) 1 ½ years 8 years 3 ½ years NA
B) 13 years
First location Subcortical Subcortical Subcortical Subcortical parieto-insular lobe & basal ganglia Subcortical (21)
periventricular posterior horn gyrus rectus & periventricular parietal lobe Cortical (1)
periventricular
Subcortical & cortical (8)
Diagnostic Stereotactic Biopsy Autopsy Stereotactic Biopsy Resection Resection (9)
Free-hand Biopsy (3)
Stereotactic Biopsy (13)
Autopsy (5)
CT and MRI-Findings T2: Diffuse hyperintense mass with perifocal edema NA in detail T1 + GL: T1: Hypointense CT: Hyperdense
Not enhanced T1+GL: Enhanced CT+CM: Enhanced
T2: Hyperintense T1: Hypointense
T2: Iso- to T1+GL: Enhanced
  hyperintense T2: Iso- to
  hyperintense
Histomorphology - Light chain deposits within vessel wall - Light chain deposits - Light chain deposits around blood vessels - Light chain deposits - Amyloid deposits
- B cell lymphoma with plasma-cellular different - around blood vessels - B cell lymphoma with abundant plasma cells - Diffuse lympho- plasmacytic B-cell lymphoma - around blood vessels
- Infiltrating T-cells - within vessel wall - Infiltrating T-cells Infiltrating T-cells - within vessel wall
- Monoclonal B- cell proliferation - In most cases NA, but in some cases lymphocytes and plasma cells
- Infiltrating T-cells
Immunohistochemistry - Congo red neg. - Congo red neg. - Congo red neg. - Congo red neg. - Congo red positive
- λ-Light chain deposits - λ-Light chain deposits - λ-Light chain deposits - λ-Light chain deposits and IgA - λ-Light chain deposits
- Plasma cells: λ-light chain >> κ-light chain - Plasma cells: λ-light chain >> κ-light chain - Ki67: 2% - Ki67: 3% - 7–12-nm fibrils
- Ki67: 1-3% - CD3+, CD5+, CD20+, CD23-, Cyclin D- - CD5+, CD38+, CD19+, CD10, CD79a-, CD138- - CD20+, CD5+, CD3+ CD38+, CD19-, CD10-, MUM1-, bcl6- - λ-light chain ++ 14/16
- κ-light chain + 2/16
  1. * N = X/30, number of patients with the presented characteristics of all presented cases of all N=30 intracerebral amyloidomas.