From: OnabotulinumtoxinA muscle injection patterns in adult spasticity: a systematic literature review
Muscles | All studies (44 studies, 58 treatment arms) | Studies reporting number of patients injected (33 studies, 46 treatment arms) | Studies reporting mean dose (26 studies, 39 treatment arms) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
k | t | Dose range (U) | k | t | n/N | Frequency (%) | k | t | n | Mean dose (U) | |
Shoulder | |||||||||||
Infraspinatus | 2 | 2 | 60 | 2 | 2 | 18/788 | 2.3 | 1 | 1 | 2 | 60.0 |
Shoulder adductors** | 1 | 1 | 30–100 | 1 | 1 | 8/788 | 1.0 | 1 | 1 | 8 | 55.6 |
Deltoid | 1 | 1 | NR | 1 | 1 | 1/788 | 0.1 | 0 | 0 | 0 | NR |
Latissimus dorsi† | 1 | 1 | 50–100 | 1 | 1 | 14/788 | 1.8 | 1 | 1 | 14 | 66.1 |
Levator scapulae | 1 | 1 | NR | 1 | 1 | 1/788 | 0.1 | 0 | 0 | 0 | NR |
Paraspinous | 1 | 1 | 100 | 1 | 1 | 1/788 | 0.1 | 1 | 1 | 1 | 100.0 |
Pectoralis | 7 | 7 | 30–100 | 5 | 5 | 39/788 | 4.9 | 3 | 3 | 22 | 67.3 |
Rhomboid | 1 | 1 | 50 | 1 | 1 | 8/788 | 1.0 | 1 | 1 | 8 | 50.0 |
Sternocleidomastoid | 1 | 1 | NR | 1 | 1 | 2/788 | 0.3 | 0 | 0 | 0 | NR |
Subscapularis | 2 | 2 | 100 | 2 | 2 | 26/788 | 3.3 | 1 | 1 | 10 | 100.0 |
Teres major | 1 | 1 | 40 | 1 | 1 | 1/788 | 0.1 | 1 | 1 | 1 | 40.0 |
Trapezius | 2 | 2 | 60 | 2 | 2 | 3/788 | 0.4 | 1 | 1 | 1 | 60.0 |
Triceps brachii | 5 | 6 | 50–100 | 4 | 4 | 10/788 | 1.3 | 3 | 3 | 9 | 73.6 |
Forearm | |||||||||||
Extensor carpi radialis | 3 | 4 | 5–50 | 3 | 4 | 6/788 | 0.8 | 2 | 3 | 4 | 17.5 |
Extensor carpi ulnaris | 1 | 2 | 5–10 | 1 | 2 | 3/788 | 0.4 | 1 | 2 | 3 | 6.7 |
Extensor digitorum | 1 | 1 | NR | 1 | 1 | 1/788 | 0.1 | 0 | 0 | 0 | NR |
Pronator quadrates | 2 | 2 | 25 | 1 | 1 | 1/788 | 0.1 | 0 | 0 | 0 | NR |
Pronator teres | 14 | 16 | 10–90 | 10 | 11 | 96/788 | 12.2 | 6 | 7 | 65 | 33.3 |
Supinator | 1 | 1 | 5 | 1 | 1 | 1/788 | 0.1 | 1 | 1 | 1 | 5.0 |
Elbow flexors | |||||||||||
Biceps brachii* | 30 | 40 | 25–200 | 19 | 27 | 306/788 | 38.8 | 16 | 24 | 263 | 95.4 |
Brachialis | 10 | 12 | 20–100 | 4 | 4 | 27/788 | 3.4 | 1 | 1 | 1 | 60.0 |
Brachioradialis | 17 | 20 | 15–200 | 9 | 11 | 104/788 | 13.2 | 7 | 9 | 75 | 41.1 |
Wrist flexors | |||||||||||
Flexor carpi radialis* | 34 | 45 | 5–100 | 24 | 34 | 504/788 | 64.0 | 18 | 28 | 433 | 49.0 |
Flexor carpi ulnaris* | 34 | 45 | 5–100 | 23 | 33 | 466/788 | 59.1 | 18 | 28 | 420 | 46.7 |
Palmaris longus | 3 | 3 | 20–25 | 2 | 2 | 8/788 | 1.0 | 1 | 1 | 4 | 23.8 |
Wrist flexors‡ | 1 | 1 | 50–120 | 1 | 1 | 20/788 | 2.5 | 1 | 1 | 20 | 72.8 |
Finger flexors | |||||||||||
Finger flexors§ | 1 | 1 | 30–160 | 1 | 1 | 20/788 | 2.5 | 1 | 1 | 20 | 97.8 |
Flexor digitorum profundus* | 31 | 39 | 5–120 | 20 | 27 | 414/788 | 52.5 | 16 | 23 | 361 | 42.0 |
Flexor digitorum superficialis* | 31 | 40 | 5–150 | 20 | 28 | 451/788 | 57.2 | 16 | 24 | 386 | 50.3 |
Forearm finger flexor | 1 | 1 | 80 | 1 | 1 | 5/788 | 0.6 | 1 | 1 | 5 | 80.0 |
Interossei volares | 1 | 1 | 10–15 | 1 | 1 | 4/788 | 0.5 | 1 | 1 | 4 | 11.3 |
Thumb | |||||||||||
Adductor pollicis | 7 | 8 | 10–20 | 5 | 6 | 102/788 | 12.9 | 3 | 4 | 93 | 18.9 |
Flexor pollicis brevis | 1 | 1 | NR | 1 | 1 | 2/788 | 0.3 | 0 | 0 | 0 | NR |
Flexor pollicis longus | 20 | 24 | 10–35 | 11 | 13 | 161/788 | 20.4 | 7 | 9 | 132 | 19.0 |
Lumbricals | 3 | 4 | 30 | 2 | 2 | 4/788 | 0.5 | 1 | 1 | 1 | 30.0 |
Opponens | 1 | 1 | 10 | 0 | 0 | NR | NR | 0 | 0 | 0 | NR |
Opponens pollicis | 2 | 2 | NR | 1 | 1 | 4/788 | 0.5 | 0 | 0 | 0 | NR |
Other muscles | |||||||||||
Other upper-limb muscles | 1 | 1 | NR | 0 | 0 | NR | NR | 0 | 0 | 0 | NR |
Upper-limb flexors | 1 | 1 | 50–150 | 0 | 0 | NR | NR | 0 | 0 | 0 | NR |