Structural and cognitive deficits in chronic carbon monoxide intoxication: a voxel-based morphometry study

BMC Neurology

Table 2 Regions of statistically significant lower GMV in chronic COI patients compared to those of controls

Gray matter volume	Anatomical regions	x	y	z	Brodmann’s area	Cluster size	T value
Normal > All patients	L Lateral Globus Pallidus	−12	8	2	-	616	5.22
	L Claustrum	−24	21	2	-	813	5.18
	R Amygdala	26	−9	−15	-	676	4.97
	R Caudate Body	9	14	8	-	374	4.78
	L Hippocampus	−33	−14	−15	-	291	4.75
	R Putamen	27	20	5	-	540	4.47
	R Supra-marginal Gyrus	50	−42	41	40	198	4.31
	L Superior Frontal Gyrus	−21	54	24	9	218	4.31
	L Post-central Gyrus	−41	−23	42	2	290	4.2
	L Hypothalamus	0	−6	−11	-	283	4.18
Normal > Chronic	L Post-central Gyrus	−42	−23	41	2	51	3.86
Normal > Delay	L Claustrum*	−24	21	2	-	2116	5.88
	R Amygdala*	29	−9	−17	-	1177	5.81
	R Caudate Body	9	14	6	-	1192	5.14
	L Hippocampus	−33	−12	−15	-	488	4.8
	R Inferior Parietal Lobule	51	−44	41	40	233	4.35
	L Superior Frontal Gyrus	−23	54	26	9	194	3.98
	L Medial Frontal Gyrus	−2	56	9	9	120	3.9
	R Anterior Cingulate	8	48	−8	32	119	3.66
	L Post-central Gyrus	−38	−21	53	3	80	3.62
	L Mammillary Body	2	−8	−11	-	63	3.59
Chronic > Delay	L Anterior Cingulate	−2	48	−11	32	2301	5.06
	R Amygdala	29	−11	−18	-	112	3.73

Voxel-based morphometry of COI patients compared to those of normal controls at an uncorrected p value (<0.001).
* Indicated for statistical threshold: uncorrected p < 0.001 with a cluster extent correction FWE-corrected p value < 0.05.
(x, y, and z) refer to the Montreal Neurological Institute coordinates. The T-value is determined by dividing the estimated regression coefficient by its standard error.
Abbreviations: R Right; L Left.

ISSN: 1471-2377