TY - JOUR AU - Kumar, Amit AU - Sagar, Ram AU - Kumar, Pradeep AU - Sahu, Jitendra K. AU - Grover, Ashoo AU - Srivastava, Achal K. AU - Vivekanandhan, S. AU - Prasad, Kameshwar PY - 2013 DA - 2013/10/03 TI - Identification of genetic contribution to ischemic stroke by screening of single nucleotide polymorphisms in stroke patients by using a case control study design JO - BMC Neurology SP - 136 VL - 13 IS - 1 AB - Stroke is the second most common cause of death and disability worldwide. It is a multi-factorial disease influenced by both environmental and genetic factors. Studies from the different ethnic regions of world have reported variable results on association of Apolioprotein E (APOE), Methylenetetrahydrofolate reductase (MTHFR), Endothelial Nitric Oxide Synthase (ENOS), Factor V Leiden (F5), Cytochrome P450 4F2 (CYP4F2), beta-fibrinogen and Phosphodiesterase 4D (PDE4D) gene in stroke. There has been substantial evidence from the European descent genetic studies showing that genetic risk of stroke varies as per specific subtypes of ischemic stroke. SN - 1471-2377 UR - https://doi.org/10.1186/1471-2377-13-136 DO - 10.1186/1471-2377-13-136 ID - Kumar2013 ER -