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Table 1 Demographic and index prescription characteristics

From: Compliance to fingolimod and other disease modifying treatments in multiple sclerosis patients, a retrospective cohort study

  Fingolimod Interferon beta-1b Intramuscular interferon beta-1a Subcutaneous interferon beta-1a Glatiramer acetate
  N=248 N=202 N=379 N=355 N=707
    p-value   p-value   p-value   p-value
Age Categories (%)    0.3112   0.1516   0.0001   0.1733
 18-24 3.2 2.5   3.4   2.0   1.8  
 25-34 10.5 17.8   13.5   19.2   15.6  
 35-44 24.6 23.3   28.0   33.2   27.4  
 45-54 37.5 33.7   27.2   31.6   33.1  
 55-64 21.0 18.3   22.4   10.1   17.8  
 65-74 3.2 4.5   5.0   3.9   3.7  
 75-84 0 0   0   0   0.6  
Age: mean (SD) 46.4 (10.7) 45.5 (11.2) 0.4107 46.5 (11.5) 0.9349 43.5 (10.7) 0.0012 45.9 (11.1) 0.5079
Female (%) 79.0 70.3 0.0330 79.7 0.8437 74.4 0.1850 76.4 0.3925
Region (%)    0.2046   0.0008   0.0984   0.0126
 Northeast 18.2 17.3   31.4   23.7   29.1  
 Midwest 29.4 27.7   28.2   33.0   27.2  
 South 32.7 41.1   28.2   26.8   27.3  
 West 19.8 13.9   12.1   15.8   16.1  
 Other/missing 0.0 0.0   0.0   0.9   0.3  
Naïve to DMT treatment (%) 38.7 82.7 <0.0001 82.6 <0.0001 72.4 <0.0001 83.7 <0.0001
Specialty of prescriber: Neurologist (%) 82.3 78.2 0.2825 74.7 0.0257 74.7 0.0270 77.5 0.1159
Index medication days supply >= 90 days (%) 0.0 0.5 0.2673 0.0 NA 0.6 0.2364 13.6 <0.0001
Prior authorization (yes) (%) 56.1 60.4 0.3527 48.6 0.0662 46.2 0.0173 47.4 0.0189
DMT on formulary (yes) (%) 15.3 71.8 <0.0001 97.9 <0.0001 85.1 <0.0001 96.2 <0.0001
Mail order (%) 74.6 51.5 <0.0001 47.0 <0.0001 54.1 <0.0001 54.0 <0.0001
Days’ Supply: mean (SD) 33.3 (16.3) 35.7 (19.5) 0.1709 35.2 (18.2) 0.2040 35.0 (18.4) 0.2302 38.8 (21.4) <0.0001
30 day Co-pay: mean (SD) 98.5 (315.5) 101.9 (291.0) 0.9063 124.1 (376.1) 0.3588 88.4 (255.6) 0.6768 119.2 (333.5) 0.3944
  1. P-values based on comparison with fingolimod cohort using Chi-square tests for categorical variables and Student's t-test for age, and Wilcoxon rank-sum tests were used for days' supply and copayment amount.
  2. DMT: disease-modifying therapy. SD: standard deviation.