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Table 1 Codes identified as high or moderate likelihood of being first ALS symptom

From: Diagnosis pathway for patients with amyotrophic lateral sclerosis: retrospective analysis of the US Medicare longitudinal claims database

  Priority Subgroup Diagnosis of interest ICD-9-CM codes
Bulbar High Speech Developmental speech, language disorder 315.39
   Speech and language deficits (including aphasia, dysphasia, voice resonance disorder, speech disturbance, dysarthria) 438.1X, 784.3, 784.4X, 784.5X
   Dysphagia 787.2, 438.82
   Swallowing Disturbance, salivary secretion 527.7
    Salivary gland disorder 527.8
   Pain, throat 784.1
Limb High Muscle strength Atrophy, muscular disuse 728.2
  Muscle weakness (generalized) 728.87
   Gait Difficulty walking 719.7
   Gait abnormality 781.2
   Lack of coordination 781.3
   Involuntary muscle movement Cramping 729.82
   Spasm 728.85
   Twitching/fasciculation 781.0
   Myopathy Myopathy (including myopathy with weakness) 359.X
  Moderate Pain Pain in joint 719.4
   Pain in limb 729.5
   Other Disorder of muscle and/or ligament 728.X
  1. ALS, amyotrophic lateral sclerosis; ICD-9-CM, International Classification of Diseases, Ninth Revision, Clinical Modification.