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Table 4 Average, median, and distribution by quarter of onset relative to ALS diagnosis for selected symptoms in the ALS cohort

From: Diagnosis pathway for patients with amyotrophic lateral sclerosis: retrospective analysis of the US Medicare longitudinal claims database

     Distribution of patients by time from symptom onset to ALS diagnosis (in quarters)
Symptom group Symptom Average, quarters Median, quarters 0–3, % 4–7, % 8–11, % 12+, %
Limb Muscle weakness 2.64 1.0 75 12 7 5
  Gait abnormality 4.53 2.0 61 12 12 15
  Difficulty in walking 5.18 3.0 52 15 21 12
  Lack of coordination 3.26 1.0 68 16 9 7
Bulbar Speech disturbance 1.83 1.0 89 7 3 1
  Voice resonance disorder 3.00 2.0 76 8 11 5
  Dysphagia 1.07 1.0 95 5 0 0
  1. ALS, amyotrophic lateral sclerosis.