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Table 3 Rate ratios and 95% confidence intervals (CIs) for subarachnoid haemorrhage occurring within a year after admission for immune-mediated disease

From: Risk of subarachnoid haemorrhage in people admitted to hospital with selected immune-mediated diseases: record-linkage studies

Immune mediated disease Observed Rate ratio (95% CI) P value
Addison’s disease 7 2.77 (1.11-5.73) 0.01
Ankylosing spondylitis 12 1.99 (1.02-3.49) 0.03
Autoimmune haemolytic anaemia 5 2.33 (0.75-5.44) 0.11
Chronic active hepatitis 0 0 (0-3.75) 0.63
Coeliac disease 23 1.62 (1.03-2.45) 0.03
Crohn’s disease 26 1.16 (0.75-1.71) 0.52
Dermatomyositis 1 1.75 (0.04-9.77) 0.93
Diabetes mellitus 144 1.68 (1.40-2.00) <0.001*
Goodpasture’s syndrome 0 0 (0-16.34) 0.56
Hashimoto’s thyroiditis 2 0.95 (0.11-3.42) 0.79
Idiopathic thrombocytopenia purpura 22 3.72 (2.32-5.66) <0.001*
Multiple sclerosis 28 1.47 (0.97-2.14) 0.06
Myasthenia gravis 4 1.44 (0.39-3.71) 0.66
Myxoedema 460 1.54 (1.38-1.72) <0.001*
Pemphigoid 7 1.91 (0.77-3.94) 0.14
Pemphigus 1 1.75 (0.04-9.77) 0.92
Pernicious anaemia 30 1.5 (1.01-2.15) 0.04
Polyarteritis nodosa 2 4.11 (0.5-14.88) 0.15
Polymyositis 2 2.12 (0.26-7.67) 0.57
Primary biliary cirrhosis 11 3.32 (1.65-5.96) <0.001*
Psoriasis 34 1.31 (0.9-1.84) 0.15
Rheumatoid arthritis 157 1.63 (1.37-1.93) <0.001*
Scleroderma 6 1.9 (0.69-4.14) 0.19
Sjogren’s syndrome 5 0.89 (0.29-2.08) 0.96
Systematic lupus erythematosus 28 4.78 (3.16-6.95) <0.001*
Thyrotoxicosis 49 1.38 (1.02-1.84) 0.03
Ulcerative colitis 31 0.87 (0.59-1.24) 0.49
  1. *Significant P value after full Bonferroni correction = <0.00185.