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Table 4 Rate ratios and 95% confidence intervals (CIs) for subarachnoid haemorrhage occurring at least a year after admission for immune-mediated disease

From: Risk of subarachnoid haemorrhage in people admitted to hospital with selected immune-mediated diseases: record-linkage studies

Immune mediated disease Observed Rate ratio (95% CI) P value
Addison’s disease 18 1.82 (1.08-2.88) 0.02
Ankylosing spondylitis 34 1.55 (1.07-2.16) 0.01
Autoimmune haemolytic anaemia 11 1.87 (0.93-3.34) 0.06
Chronic active hepatitis 1 0.21 (0.01-1.2) 0.14
Coeliac disease 49 0.89 (0.66-1.18) 0.48
Crohn’s disease 133 1.32 (1.11-1.57) 0.002
Dermatomyositis 2 1.11 (0.13-4.02) 0.83
Diabetes mellitus 390 1.10 (0.99-1.22) 0.067
Goodpasture’s syndrome 2 3.12 (0.38-11.27) 0.28
Hashimoto’s thyroiditis 8 0.97 (0.42-1.91) 0.93
Idiopathic thrombocytopenia purpura 40 2.04 (1.45-2.78) <0.001*
Multiple sclerosis 87 1 (0.8-1.24) 0.97
Myasthenia gravis 8 0.79 (0.34-1.55) 0.61
Myxoedema 823 1.02 (0.95-1.1) 0.53
Pemphigoid 9 1.03 (0.47-1.96) 0.94
Pemphigus 2 1.21 (0.15-4.37) 0.91
Pernicious anaemia 66 1.22 (0.95-1.56) 0.12
Polyarteritis nodosa 2 1.15 (0.14-4.15) 0.85
Polymyositis 6 1.72 (0.63-3.75) 0.28
Primary biliary cirrhosis 19 1.86 (1.12-2.9) 0.01
Psoriasis 122 1.35 (1.12-1.62) 0.001*
Rheumatoid arthritis 483 1.44 (1.31-1.58) <0.001*
Scleroderma 19 1.83 (1.1-2.85) 0.012
Sjogren’s syndrome 34 1.94 (1.35-2.72) <0.001*
Systematic lupus erythematosus 80 3.5 (2.77-4.36) <0.001*
Thyrotoxicosis 153 1.38 (1.16-1.62) <0.001*
Ulcerative colitis 167 1.03 (0.88-1.2) 0.71
  1. *Significant P value after full Bonferroni correction = <0.00185.