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Table 3 Results of the regression analysis

From: Relating relapse and T2 lesion changes to disability progression in multiple sclerosis: a systematic literature review and regression analysis

Model

Predictor

Slope

p-value

Lower 95% CI

Upper 95% CI

Adjusted R2

RRMS, All DMTs

Annual relapse ratio log-ratio

0.531

< 0.001

0.425

9.637

0.750

RRMS, Approved DMTs

Annual relapse ratio log-ratio

0.500

< 0.001

0.338

0.663

0.670

SPMS and SPMS Mixed

Annual relapse ratio log-ratio

0.397

0.027

0.060

0.735

0.414

RRMS, All DMTs

T2 median volume log-ratio

1.953

0.015

0.428

3.477

0.247

RRMS, Approved DMTs

T2 median volume log-ratio

1.407

0.018

0.281

2.533

0.3305

RRMS, Not Approved

T2 median volume log-ratio

3.978

0.151

-2.055

10.011

0.238

SPMS and SPMS Mixed

T2 median volume log-ratio

NA

NA

NA

NA

NA

RRMS, All DMTs

T2 lesion count log-ratio

0.138

< 0.001

0.079

0.196

0.706

RRMS, Approved DMTs

T2 lesion count log-ratio

0.162

0.025

0.027

0.298

0.467

SPMS and SPMS Mixed

T2 lesion count log-ratio

NA

NA

NA

NA

NA

  1. DMT, disease-modifying treatment; RRMS, relapsing-remitting multiple sclerosis; SPMS, secondary progressive multiple sclerosis; NA, not available.