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Table 3 Results of the regression analysis

From: Relating relapse and T2 lesion changes to disability progression in multiple sclerosis: a systematic literature review and regression analysis

Model Predictor Slope p-value Lower 95% CI Upper 95% CI Adjusted R2
RRMS, All DMTs Annual relapse ratio log-ratio 0.531 < 0.001 0.425 9.637 0.750
RRMS, Approved DMTs Annual relapse ratio log-ratio 0.500 < 0.001 0.338 0.663 0.670
SPMS and SPMS Mixed Annual relapse ratio log-ratio 0.397 0.027 0.060 0.735 0.414
RRMS, All DMTs T2 median volume log-ratio 1.953 0.015 0.428 3.477 0.247
RRMS, Approved DMTs T2 median volume log-ratio 1.407 0.018 0.281 2.533 0.3305
RRMS, Not Approved T2 median volume log-ratio 3.978 0.151 -2.055 10.011 0.238
SPMS and SPMS Mixed T2 median volume log-ratio NA NA NA NA NA
RRMS, All DMTs T2 lesion count log-ratio 0.138 < 0.001 0.079 0.196 0.706
RRMS, Approved DMTs T2 lesion count log-ratio 0.162 0.025 0.027 0.298 0.467
SPMS and SPMS Mixed T2 lesion count log-ratio NA NA NA NA NA
  1. DMT, disease-modifying treatment; RRMS, relapsing-remitting multiple sclerosis; SPMS, secondary progressive multiple sclerosis; NA, not available.