Skip to main content

Table 4 Comparison of cognitive performance between SCA14 affected subjects and intrafamilial controls

From: Cognition is only minimally impaired in Spinocerebellar ataxia type 14 (SCA14): a neuropsychological study of ten Norwegian subjects compared to intrafamilial controls and population norm

 

Norm data

Affectedn = 9

Intrafamilial controlsn = 10

Affected vs norm

Controls vs norm

Affected vs controls

Subject, V-10**

SubjectIII 3***

    

One-sample t-test

One-sample t-test

MannWhitney U test

  
 

Mean

Median ± interquartile range

Median ± interquartile range

p-value*

p-value*

p-value*

Scores

Scores

General cognitive functioning

        

 Intelligence Quotient (IQ)

100

92.0 ± 10

100.5 ± 18

0.020

0.563

0.288

91

92

 Vocabulary (t-score)

50

41.0 ± 8

44.0 ± 14

0.001

0.194

0.120

43

39

 Matrix Reasoning (t-score)

50

53.0 ± 11

51.5 ± 18

0.479

0.602

1.000

47

52

Verbal executive function

        

 Controlled Word Fluency Test, Phonologic (FAS) t-score

50

45.0 ± 6

46.5 ± 9

0.003

0.174

0.410

43

40

 Controlled Word Fluency Test, Semantic t-score

50

53.0 ± 9

53.0 ± 9

0.506

0.200

0.711

47

55

Learning and memory

        

 CVLT Learning percentil

50

59.0 ± 11

48.0 ± 9

0.866

0.866

0.041

52

65

 CVLT Long-Delay Free Recall

10

14.0 ± 2

12.0 ± 2

<0.001

0.005

0.065

9

12

 CVMT Learning percentil

50

10.3 ± 42.2

11.5 ± 19.3

0.022

<0.001

0.806

8.6

10.3

 CVMT Memory percentil

50

27.6 ± 59.6

15.1 ± 10.8

0.278

<0.001

0.135

13.8

27.6

Visuoperceptive skills

        

 Line Orientation Test

25.4

27.0 ± 11

28.0 ± 3

0.359

0.288

0.136

19

17

Working memory

        

 Digit Span, sub-test, WAIS-R

10

10.0 ± 5

10.0 ± 3

0.540

0.310

0.868

8

10

 Paced Auditory Serial Addition Test PASAT

46

39.0 ± 22

38.5 ± 10

0.049

0.036

0.653

****

32

Psychomotor speed

        

 Stroop Color Naming Test 1

10

7.0 ± 3

9.5 ± 5

<0.001

0.111

0.284

7

6

 Stroop Color Naming Test 2

10

7.0 ± 2

7.0 ± 5

0.003

0.026

0.706

3

7

Executive functions, inhibition and set-shifting

        

 Stroop Color Naming Test 3

10

9.0 ± 4

9.0 ± 3

0.373

0.327

0.868

3

12

 Stroop Color Naming Test 4

10

9.0 ± 4

10.5 ± 3

0.111

0.842

0.137

6

9

 WCST total errors t-score

50

53.0 ± 20

38.5 ± 10

0.928

0.005

0.141

46

56

 WCST categories

5.1

6.0 ± 1

5.5 ± 2

*****

*****

0.257

5

6

 WCST conceptual level responses t-score

50

52.0 ± 20

39.0 ± 6

0.977

0.001

0.093

47

58

 WCST perseverative responses t-score

50

55.0 ± 26

37.0 ± 12

0.661

0.002

0.064

49

55

  1. *p-values < 0.05 are highlighted in bold.
  2. **Subject V-10’s individual scores. V-10 is confirmed to carry SCA14 mutation, but was motor asymptomatic and not included in group analyses.
  3. ***Subject III-3’s individual scores. III-3 is the only subject from Family 2, and is also included in affected group analyses.
  4. ****Subject V-10 did not fulfill PASAT test.
  5. *****not available for t-test due to not normal distribution.
Back to article page

BMC Neurology

ISSN: 1471-2377

Contact us