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Table 4 Comparison of cognitive performance between SCA14 affected subjects and intrafamilial controls

From: Cognition is only minimally impaired in Spinocerebellar ataxia type 14 (SCA14): a neuropsychological study of ten Norwegian subjects compared to intrafamilial controls and population norm

  Norm data Affectedn = 9 Intrafamilial controlsn = 10 Affected vs norm Controls vs norm Affected vs controls Subject, V-10** SubjectIII 3***
     One-sample t-test One-sample t-test MannWhitney U test   
  Mean Median ± interquartile range Median ± interquartile range p-value* p-value* p-value* Scores Scores
General cognitive functioning         
 Intelligence Quotient (IQ) 100 92.0 ± 10 100.5 ± 18 0.020 0.563 0.288 91 92
 Vocabulary (t-score) 50 41.0 ± 8 44.0 ± 14 0.001 0.194 0.120 43 39
 Matrix Reasoning (t-score) 50 53.0 ± 11 51.5 ± 18 0.479 0.602 1.000 47 52
Verbal executive function         
 Controlled Word Fluency Test, Phonologic (FAS) t-score 50 45.0 ± 6 46.5 ± 9 0.003 0.174 0.410 43 40
 Controlled Word Fluency Test, Semantic t-score 50 53.0 ± 9 53.0 ± 9 0.506 0.200 0.711 47 55
Learning and memory         
 CVLT Learning percentil 50 59.0 ± 11 48.0 ± 9 0.866 0.866 0.041 52 65
 CVLT Long-Delay Free Recall 10 14.0 ± 2 12.0 ± 2 <0.001 0.005 0.065 9 12
 CVMT Learning percentil 50 10.3 ± 42.2 11.5 ± 19.3 0.022 <0.001 0.806 8.6 10.3
 CVMT Memory percentil 50 27.6 ± 59.6 15.1 ± 10.8 0.278 <0.001 0.135 13.8 27.6
Visuoperceptive skills         
 Line Orientation Test 25.4 27.0 ± 11 28.0 ± 3 0.359 0.288 0.136 19 17
Working memory         
 Digit Span, sub-test, WAIS-R 10 10.0 ± 5 10.0 ± 3 0.540 0.310 0.868 8 10
 Paced Auditory Serial Addition Test PASAT 46 39.0 ± 22 38.5 ± 10 0.049 0.036 0.653 **** 32
Psychomotor speed         
 Stroop Color Naming Test 1 10 7.0 ± 3 9.5 ± 5 <0.001 0.111 0.284 7 6
 Stroop Color Naming Test 2 10 7.0 ± 2 7.0 ± 5 0.003 0.026 0.706 3 7
Executive functions, inhibition and set-shifting         
 Stroop Color Naming Test 3 10 9.0 ± 4 9.0 ± 3 0.373 0.327 0.868 3 12
 Stroop Color Naming Test 4 10 9.0 ± 4 10.5 ± 3 0.111 0.842 0.137 6 9
 WCST total errors t-score 50 53.0 ± 20 38.5 ± 10 0.928 0.005 0.141 46 56
 WCST categories 5.1 6.0 ± 1 5.5 ± 2 ***** ***** 0.257 5 6
 WCST conceptual level responses t-score 50 52.0 ± 20 39.0 ± 6 0.977 0.001 0.093 47 58
 WCST perseverative responses t-score 50 55.0 ± 26 37.0 ± 12 0.661 0.002 0.064 49 55
  1. *p-values < 0.05 are highlighted in bold.
  2. **Subject V-10’s individual scores. V-10 is confirmed to carry SCA14 mutation, but was motor asymptomatic and not included in group analyses.
  3. ***Subject III-3’s individual scores. III-3 is the only subject from Family 2, and is also included in affected group analyses.
  4. ****Subject V-10 did not fulfill PASAT test.
  5. *****not available for t-test due to not normal distribution.