Figure 1
From: Cortical GABAergic neurons are more severely impaired by alkalosis than acidosis
The spike encoding processes of cortical GABAergic neurons are more vulnerable to alkalosis than acidosis by their influence on refractory periods and threshold potentials mediated by voltage-gated sodium channels. A) Superimposed waveforms show refractory periods measured by identical protocols under the conditions of control (red trace), acidosis (blue) and alkalosis (dark-blue). B) shows statistical results in the net changes of spike RPs under the conditions of acidosis (gray bar) and alkalosis (dark-gray, an asterisk, p < 0.05; n = 15). C) illustrates ΔVts under the conditions of acidosis (gray bar) and alkalosis (dark-gray, an asterisk, p < 0.05; n = 15).