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Figure 4 | BMC Neurology

Figure 4

From: Cortical GABAergic neurons are more severely impaired by alkalosis than acidosis

Figure 4

Cortical GABAergic synapses are more vulnerable to alkalosis than acidosis. A~C) Waveforms from top to bottom panels show the recorded sIPSCs under the conditions of control (A), acidosis (B) and alkalosis (C), respectively. The bottom waveforms from each of them are sIPSCs expanded from asterisk-indicated events. Calibration bars are 10 pA, 200 ms for top traces and 5 ms for the expanded traces. D) shows statistical comparison in the net changes (Δ) of sIPSC amplitudes versus cumulative changes under the conditions of acidosis versus control (open symbols) and alkalosis versus control (dark symbols, n = 10; p < 0.05). E) illustrates the statistical comparison in the net changes (Δ) of inter-sIPSC-intervals versus cumulative changes under the conditions of acidosis versus control (open symbols) and alkalosis versus control (dark symbols, p < 0.01; n = 10).

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