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Table 1 List of tested blood biomarkers

From: Biomarkers and perfusion – training-induced changes after stroke (BAPTISe): protocol of an observational study accompanying a randomized controlled trial

Blood biomarkers

Time points

Baseline (t1)

t1+ 4 weeks (t2)

3 months post stroke (t3)

6 months post stroke (t4)

Glucose

X

X

X

X

HbA1c

X

X

X

X

INR

X

   

PTT

X

   

Fibrinogen

X

X

X

X

LDL

X

X

X

X

HDL

X

X

X

X

Triglycerides

X

X

X

X

Lipoprotein a

X

X

X

X

Full blood count

X

X

X

X

Transaminases

X

X

X

X

Creatinine

X

X

X

X

Cortisol

X

X

X

X

Insulin

X

X

X

X

TSH

X

 

X

 

fT3

(X)

 

(X)

 

fT4

(X)

 

(X)

 

FSH

   

X

LH

   

X

Testosterone

   

X

Estradiol

   

X

hs-CRP

X

X

X

X

TNF-alpha

X

X

X

X

IL-6

X

X

X

X

HLA-DR

X

 

X

X

Lymphocyte subpopulations

X

 

X

X

LBP

X

 

X

X

MBL

X

 

X

X

Copeptin

X

 

X

X

proANP

X

 

X

X

IL-1b

RS

RS

RS

RS

BDNF

RS

RS

RS

RS

IGF-1

RS

RS

RS

RS

IGFBP-3

RS

RS

RS

RS

G-CSF

RS

RS

RS

RS

NGF

RS

RS

RS

RS

Endothelial progenitor cells

RS

RS

RS

RS

Endothelial microparticles

RS

RS

RS

RS

Endoglin

RS

RS

RS

RS

Apelin

RS

RS

RS

RS

Irisin

RS

RS

RS

RS

CNTF

RS

RS

RS

RS

GFAP

RS

RS

RS

RS

VEGF

RS

RS

RS

RS

VEGFR

RS

RS

RS

RS

Other

RS

RS

RS

RS

  1. Spectrum of blood biomarkers assessed in the first 24 patients. Parameters which have proved to be most pertinent will be further evaluated in the following patients of BAPTISe.
  2. X = biomarker detection; (X) = detection if TSH is abnormal; RS = reserve samples for later testing. HbA1c: glycated hemoglobin; INR: international normalized ration; PTT: partial thromboplastin time; LDL: low-density lipoprotein; HDL: high-density lipoprotein; TSH: thyreotropin; fT3: triiodothyronine; fT4: thyroxine; FSH: follicle-stimulating hormone; LH: luteinizing hormone; TNF-alpha: tumor necrosis factor alpha; IL-6: interleukin-6; HLA-DR: human leucocyte antigen-DR; LBP: lipopolysaccharide-binding protein; MBL: mannose-binding lectin; pro-ANP: pro-atrial natriuretic peptide BDNF: brain-derived neurotrophic factor; IGF-1: insulin-like growth factor 1; IGFBP-3: insulin-like growth factor-binding protein 3; G-CSF: granulocyte colony-stimulating factor; CNTF: ciliary neurotrophic factor; GFAP: glial fibrillary acidic protein; VEGF: vascular endothelial growth factor; VEGFR: vascular endothelial growth factor receptor.
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BMC Neurology

ISSN: 1471-2377

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