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Table 1 Demographic and clinical characteristics of HCs, all MS patients, and MS subtypes

From: Chronic cerebrospinal venous insufficiency in multiple sclerosis: a highly prevalent age-dependent phenomenon

  Disease group (n)
  HCs (38) All MS (146) P value CIS (16) PPMS (19) RRMS (53) SPMS (58) P value
Age (y) 37±10 40±9 0.112 32±7 48±11 37±9 43±7 0.001a
mean (±SD)
M/F 18/20 49/97 0.115 6/10 6/13 13/40 17/41 0.001b
EDSS   4   2.3 5.5 3.0 5.0 0.001a
median (range)   (1.5-7.0)   (1.5-3.5) (3.5-7.0) (2.0-5.0) (2.5-7.0)
MSSS   5.3   6.3 5.3 5.4 4.9 0.122
median (range)   (1.2-9.5)   (2.1-8.6) (3.7-9.1) (1.5-8.6) (1.6-9.4)
Disease duration (y)   11   1 13 7 16 0.001a
median (range)   (0–35)   (0–11) (4–24) (1–29) (3–35)
Onset age (y)   28.0   29.3 35.0 27.6 27.0 0.036c
median (range)   (13.0-57.0)   (18.5-41.0) (18–57) (15–46) (13–44)
  1. aAge, EDSS, and disease duration were significantly higher in PPMS and SPMS patients than in CIS and RRMS patients.
  2. bMale sex was significantly prevalent in PP patients.
  3. cOnset age was significantly higher in PPMS patients than in RR and SP patients.
  4. Abbreviations: CIS: clinically isolated syndrome; HCs: healthy controls; MS: multiple sclerosis; PPMS: primary progressive multiple sclerosis; RRMS: relapsing-remittent multiple sclerosis; SPMS: secondary progressive multiple sclerosis.