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Table 5 Neurologic symptoms and brain MRI patterns in the PML and herpesvirus-positive patient groups

From: Detection of human herpesviruses in the cerebrospinal fluid from patients diagnosed with or suspected of having progressive multifocal leukoencephalopathy

   

MRI(T2/FLAIR) lesion (%)a

Detected

No. of patients

Neurologic symptom (%)

Cerebral white matter

    

Viral DNA in CSF

Cerebellum

Brain stem

Other

Unknown

JCVb

25

25 (100)

21 (84.0)

4 (16.0)

7 (28.0)

2 (8.0)

2 (8.0)

Herpesvirusesc

24

20 (83.3)

18 (75.0)

7 (29.2)

2 (8.3)

3 (12.5)

1 (4.2)

HSV-1 and CMV

1

1 (100)

1 (100)

0 (0)

0 (0)

0 (0)

0 (0)

VZV

6

6 (100)

5 (83.3)

1 (16.7)

1 (16.7)

0 (0)

1 (16.7)

VZV or EBV

1

1 (100)

1 (100)

1 (100)

0 (0)

1 (100)

0 (0)

CMV

3

2 (66.7)

3 (100)

0 (0)

0 (0)

0 (0)

0 (0)

CMV and EBV

1

1 (100)

1 (100)

0 (0)

0 (0)

0 (0)

0 (0)

EBV

12

9 (75.0)

7 (58.3)

5 (41.7)

1 (8.3)

2 (16.7)

0 (0)

  1. aThe data include patients with multiple lesion sites.
  2. bThe patients were negative for herpesvirus DNA in their CSF.
  3. cThe patients were negative for JCV DNA in their CSF.
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BMC Neurology

ISSN: 1471-2377

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