Study protocol to examine the effects of spaceflight and a spaceflight analog on neurocognitive performance: extent, longevity, and neural bases

Table 1 Testing timeline for astronauts and bed rest subjects

Astronauts	Pre launch					Flight day						Return
Day:	-180	-90				30	90	150				+90	+180
Bed rest subjects	Pre bed rest		In bed rest						Post bed rest
Day:	-12	-7	7	30	65-70				+0	+8	+12
Behavioral measures
Thurston's card rotation task	X	X	X	X	X					X	X	X	X
Cube mental rotation task	X	X	X	X	X	X	X	X		X	X	X	X
Rod and frame test	X	X	X	X	X					X	X	X	X
Digit symbol substitution task of the WAIS	X	X	X	X	X					X	X	X	X
Purdue pegboard test	X	X	X	X	X					X	X	X	X
Computerized dynamic posturography	X	X							X	X	X	X	X
Functional mobility test	X	X							X	X	X	X	X
Structural neuro-imaging
High resolution T1‒weighted imaging	X	X	X	X	X					X	X	X	X
Diffusion tensor imaging	X	X	X	X	X					X	X	X	X
Functional neuro-imaging
Functional connectivity MRI	X	X	X	X	X				X	X	X	X	X
VEMP	X	X	X	X	X				X	X	X	X	X
Dual task	X	X	X	X	X	•	•	•	X	X	X	X	X
Sensorimotor adaptation task	X	X	X	X	X	•	•	•	X	X	X	X	X
Spatial working memory task	X	X	X	X	X				X	X	X	X	X
Foot tapping	X	X	X	X	X				X	X	X	X	X

WAIS = Wechsler adult intelligence scale; MRI = Magnetic resonance imaging; VEMP = Vestibular evoked myogenic potential; ● = fMRI paradigms of which the behavioral measure is completed while in space.