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Table 3 LINGO1 genotypes and allelic variants in patients with MS, and relation with the evolutive type of MS

From: LINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis

 

RELAPSING-REMITTING MS (N = 159; 318 ALLELES)

Intergroup comparison values

SECONDARY PROGRESSIVE MS (N = 91; 182 ALLELES)

Intergroup comparison values

PRIMARY PROGRESSIVE MS (N = 43; 86 ALLELES)

Intergroup comparison values

CONTROLS (N = 318, 636 ALLELES)

rs9652490 GENOTYPE

A/A

102 (64.2%)

 

62 (68.1%)

 

33 (76.7%)

 

222 (69.8%)

A/G

56 (35.2%)

P = 0.055

26 (28.6%)

P =0.956

10 (23.3%)

P = 0.405

86 (27.0%)

G/G

1 (0.6%)

 

3 (3.3%)

 

0 (0.0%)

 

10 (3.1%)

Allele A

260 (81.8%)

--

150 (82.4%)

--

76 (88.4%)

--

530 (83.3%)

Allele G

58 (18.2%)

OR (95% CI)

32 (17.6%)

OR (95% CI)

10 (11.6%)

OR (95% CI)

106 (16.7%)

1.12 (0.78-1.59)

1.07 (0.69-1.65)

0.66 (0.33-1.31)

P = 0.544

P = 0.771

P = 0.232

rs11856808 GENOTYPE

C/C

67 (42.1%)

 

43 (47.3%)

 

27 (62.8%)

 

145 (45.6%)

C/T

77 (48.4%)

P = 0.670

35 (38.5%)

P = 0.095

14 (32.6%)

P = 0.112

149 (46.9%)

T/T

15 (9.4%)

 

13 (14.3%)

 

2 (4.7%)

 

24 (7.5%)

Allele C

211 (66.4%)

--

121 (66.5%)

--

68 (79.1%)

--

439 (69.0%)

Allele T

107 (33.6%)

OR (95% CI)

61 (33.5%)

OR (95% CI)

18 (20.9%)

OR (95% CI)

197 (31.0%)

  

1.13 (0.85-1.51)

 

1.12 (0.79-1.60)

 

0.59 (0.34-1.02)

 
  

P = 0.404

 

P = 0.515

 

P = 0.056

 
  1. P values correspond to 3x2 contingency tables (exact test).