Table 3 Frequency of plaque pathology scores for ApoE ϵ4 carriers and non-carriers by age group
From: The influence of Apolipoprotein E genotype on regional pathology in Alzheimer’s disease
Age group | ≤69 | 70 - 79 | 80 - 89 | ≥90 | |||||
|---|---|---|---|---|---|---|---|---|---|
ϵ4+ | ϵ4 - | ϵ4+ | ϵ4 - | ϵ4+ | ϵ4 - | ϵ4+ | ϵ4 - | ||
Frontal Plaque Density | None | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (1%) |
Sparse | 0 (0%) | 0 (0%) | 1 (0.7%) | 1 (0.7%) | 0 (0%) | 3 (1.1%) | 0 (0%) | 1 (1%) | |
Moderate | 2 (5.1%) | 1 (2.6%) | 5 (3.6%) | 8 (5.8%) | 5 (1.8%) | 13 (4.6%) | 2 (2%) | 11 (10.8%) | |
Frequent | 21 (58.9%) | 15 (38.5%) | 86 (61.87%) | 38 (27.3%) | 147 (52.5%) | 112 (40%) | 38 (37.3%) | 49 (48%) | |
p = 0.78 | p = 0.03 | p = 0.003 | p = 0.03 | ||||||
Temporal Plaque Density | None | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
Sparse | 0 (0%) | 0 (0%) | 0 (0%) | 2 (1.4%) | 0 (0%) | 3 (1.1%) | 0 (0%) | 2 (2%) | |
Moderate | 1 (2.6%) | 0 (0%) | 7 (5.0%) | 6 (4.3%) | 7 (2.5%) | 21 (7.5%) | 2 (2%) | 8 (7.9%) | |
Frequent | 22 (56.4%) | 16 (41.0%) | 85 (61.2%) | 39 (28.1%) | 146 (52.1%) | 103 (36.8%) | 38 (37.6%) | 51 (50.5%) | |
p = 0.40 | p = 0.08 | p < 0.001 | p = 0.08 | ||||||
Parietal Plaque Density | None | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 2 (2%) |
Sparse | 0 (0%) | 0 (0%) | 0 (0%) | 1 (0.7%) | 0 (0%) | 1 (0.4%) | 0 (0%) | 1 (1%) | |
Moderate | 0 (0%) | 0 (0%) | 5 (3.6%) | 6 (4.4%) | 3 (1.1%) | 14 (5%) | 1 (1%) | 7 (7%) | |
Frequent | 23 (59%) | 16 (41%) | 87 (63%) | 39 (28.3%) | 148 (53.1%) | 113 (40.5%) | 39 (39%) | 50 (50%) | |
p = 0.99 | p = 0.05 | p = 0.001 | p = 0.03 | ||||||
Hippocampal Plaque Density | None | 0 (0%) | 0 (0%) | 2 (1.5%) | 7 (5.1%) | 3 (1.1%) | 11 (3.9%) | 0 (0%) | 8 (8%) |
Sparse | 3 (7.7%) | 1 (2.6%) | 5 (3.6%) | 6 (4.4%) | 18 (6.4%) | 38 (13.6%) | 9 (9%) | 15 (15%) | |
Moderate | 4 (10.3%) | 6 (15.4%) | 44 (31.9%) | 18 (13%) | 70 (25%) | 41 (14.6%) | 15 (15%) | 23 (23%) | |
Frequent | 16 (41%) | 9 (23.1%) | 40 (29%) | 16 (11.6%) | 62 (22.1%) | 37 (13.2%) | 16 (16%) | 14 (14%) | |
p = 0.56 | p = 0.03 | p < 0.001 | p = 0.02 | ||||||
Entorhinal Plaque Density | None | 0 (0%) | 0 (0%) | 1 (0.7%) | 4 (2.9%) | 2 (0.7%) | 2 (0.7%) | 1 (1%) | 3 (3%) |
Sparse | 0 (0%) | 0 (0%) | 1 (0.7%) | 5 (3.6%) | 3 (1.1%) | 13 (4.6%) | 1 (1%) | 1 (1%) | |
Moderate | 2 (5.1%) | 2 (5.1%) | 22 (15.8%) | 14 (10.1%) | 38 (13.6%) | 39 (13.9%) | 9 (8.9%) | 24 (23.8%) | |
Frequent | 21 (53.9%) | 14 (35.9%) | 68 (48.9%) | 24 (17.3%) | 110 (39.3%) | 73 (26.1%) | 29 (28.7%) | 33 (32.7%) | |
p = 0.70 | p = 0.002 | p = 0.005 | p = 0.08 | ||||||