Table 4 Frequency of tangle pathology scores for ApoE ϵ4 carriers and non-carriers by age group
From: The influence of Apolipoprotein E genotype on regional pathology in Alzheimer’s disease
Age group | ≤69 | 70 - 79 | 80 - 89 | ≥90 | |||||
|---|---|---|---|---|---|---|---|---|---|
ϵ4+ | ϵ4 - | ϵ4+ | ϵ4 - | ϵ4+ | ϵ4 - | ϵ4+ | ϵ4 - | ||
Frontal Tangle Density | None | 1 (2.6%) | 0 (0%) | 14 (10.2%) | 11 (8%) | 20 (7.1%) | 36 (12.9%) | 6 (5.9%) | 19 (18.6%) |
Sparse | 1 (2.6%) | 0 (0%) | 13 (9.4%) | 8 (6%) | 31 (11.1%) | 36 (12.9%) | 10 (9.8%) | 21 (20.6%) | |
Moderate | 0 (0%) | 0 (0%) | 8 (5.8%) | 5 (3.6%) | 27 (9.6%) | 10 (3.6%) | 6 (5.9%) | 10 (9.8%) | |
Frequent | 21 (53.9%) | 16 (41.3%) | 56 (40.9%) | 23 (16.7%) | 74 (26.4%) | 46 (16.4%) | 18 (17.7%) | 12 (11.8%) | |
p = 0.23 | p = 0.14 | p = 0.001 | p = 0.006 | ||||||
Temporal Tangle Density | None | 1 (2.6%) | 0 (0%) | 8 (5.8%) | 8 (5.8%) | 9 (3.2%) | 13 (4.6%) | 1 (1%) | 8 (7.9%) |
Sparse | 1 (2.6%) | 0 (0%) | 9 (6.5%) | 7 (5.1%) | 12 (4.3%) | 30 (10.7%) | 9 (8.9%) | 15 (14.9%) | |
Moderate | 0 (0%) | 0 (0%) | 10 (7.3%) | 4 (2.9%) | 14 (5%) | 20 (7.1%) | 3 (3%) | 12 (11.9%) | |
Frequent | 21 (53.9%) | 16 (41.3%) | 64 (46.4%) | 28 (20.3%) | 118 (42.1%) | 64 (22.9%) | 27 (26.7%) | 26 (25.7%) | |
p = 0.46 | p = 0.13 | p < 0.001 | p = 0.02 | ||||||
Parietal Tangle Density | None | 2 (5.1%) | 0 (0%) | 16 (11.7%) | 12 (8.8%) | 18 (6.5%) | 42 (15.1%) | 8 (8.1%) | 20 (20.2%) |
Sparse | 0 (0%) | 0 (0%) | 9 (6.6%) | 6 (4.4%) | 30 (10.8%) | 25 (9%) | 10 (10.1%) | 18 (18.2%) | |
Moderate | 1 (2.6%) | 1 (2.6%) | 6 (4.4%) | 4 (2.9%) | 27 (9.7%) | 13 (4.7%) | 6 (6.1%) | 9 (9.1%) | |
Frequent | 20 (51.3%) | 15 (38.5%) | 60 (43.8%) | 24 (17.5%) | 76 (27.2%) | 48 (17.2%) | 16 (16.2%) | 12 (12.1%) | |
p = 0.23 | p = 0.12 | p < 0.001 | p = 0.03 | ||||||
Hippocampal Tangle Density | None | 1 (2.6%) | 0 (0%) | 3 (2.2%) | 5 (3.6%) | 1 (0.4%) | 6 (2.2%) | 0 (0%) | 3 (3%) |
Sparse | 1 (2.6%) | 0 (0%) | 3 (2.2%) | 8 (5.8%) | 7 (2.5%) | 11 (4%) | 2 (2%) | 9 (9%) | |
Moderate | 0 (0%) | 0 (0%) | 6 (4.3%) | 5 (3.6%) | 13 (4.7%) | 21 (7.6%) | 0 (0%) | 7 (7%) | |
Frequent | 21 (53.9%) | 16 (41%) | 80 (57.6%) | 29 (20.9%) | 130 (46.8%) | 89 (32%) | 28 (38%) | 41 (41%) | |
p = 0.23 | p < 0.001 | p = 0.001 | p = 0.002 | ||||||
Entorhinal Tangle Density | None | 0 (0%) | 0 (0%) | 1 (0.7%) | 1 (0.7%) | 0 (0%) | 1 (0.4%) | 0 (0%) | 0 (0%) |
Sparse | 1 (2.6%) | 0 (0%) | 1 (0.7%) | 4 (2.8%) | 1 (0.4%) | 6 (2.2%) | 0 (0%) | 1 (1%) | |
Moderate | 1 (2.6%) | 0 (0%) | 5 (3.6%) | 3 (2.2%) | 3 (1.1%) | 16 (5.8%) | 1 (1%) | 10 (10%) | |
Frequent | 21 (53.9%) | 16 (41%) | 85 (61.2%) | 39 (28.1%) | 147 (53.1%) | 103 (45.5%) | 38 (38%) | 50 (50%) | |
p = 0.23 | p = 0.08 | p < 0.001 | p = 0.02 | ||||||