Table 2 The clinically investigated group - diagnosis and levels of CSF biomarkers, median (range)
From: Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia
| Â | FTD (n=34) | bvFTD (n=23) | SD (n=7) | PNFA (n=4) | AD (n=20) | Controls(n=26) | Significance |
|---|---|---|---|---|---|---|---|
NFL (ng/L) | 844 (250–2760) | 770 (250–2760) | 1340 (580–1940) | 455 (250–1040) | 415 (250–860) | 250 (250–710) | FTD> AD p<0.001 SD>AD p<0.001 FTDbv> AD p<0.001 |
Aβ42 (ng/L) | 555 (140–1130) | 570 (260–1130) | 595(360–1110) | 215 (140–380) | 285 (140–460) | NA | FTD>AD p<0.001 |
Tau (ng/L) | 355 (150–820) | 280 (160–750) | 385(180–770) | 610 (150–820) | 630 (230–2290) | NA | AD>FTD p<0.001 |
p-tau (ng/L) | 49 (23–115) | 45(29–82) | 55 (23–92) | 88 (45–115) | 87 (42–237) | NA | AD<FTD p<0.001 |
Albumin ratio | 0.00755 (0.0025-0.0346) | 0.00765 (0.0043-0.0346) | 0.00655 (0.0051-0.0134) | 0.0058 (0.0025-0.0081) | 0.00665 (0.0033-0.0099) | NA | Non-significant |