ECM down-regulation in OPMD patients. A. Gene ontology trees of the extracellular region component and binding molecular function of ECM localized components are significantly deregulated in the human OPMD transcriptome. P-values indicated for each GO-term were calculated by Global test. Between hyphens the numbers of deregulated genes (left) and the total number of annotated genes per GO-term (right) are indicated. B. ECM and Collagen encoding genes are predominantly deregulated in OPMD. Histogram shows the percentage of up-regulated and down-regulated genes in the ECM and Collagen GO categories.