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Figure 6 | BMC Neurology

Figure 6

From: Nuclear entrapment and extracellular depletion of PCOLCE is associated with muscle degeneration in oculopharyngeal muscular dystrophy

Figure 6

Reduction of Pcolce signal at the ECM in the OPMD model mice. (A) Immunofluorescence staining of TA muscle sections of 12- and 26-week old wild type (FVB) and A17.1 OPMD model mice was conducted with anti-Pcolce antibodies (red). DAPI staining of nuclear DNA (blue) is merged. Some nuclei with entrapped Pcolce are indicated with arrows. Scale bars are 20 μm. (B) Immunolocalisation of Pcolce in sections from 12 and 18-week old A17.1 mice was conducted in combination with anti-dysferlin (green), which marks the sarcolemma of skeletal muscles. Some nuclei with entrapped Pcolce are indicated with arrows. Scale bars are 10 μm. Immunostaining was performed on sections from 3 mice for each genotype. Shown are representative images.

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