No sex-specific difference in disease trajectory in multiple sclerosis patients before and after age 50

BMC Neurology

Table 3 Longitudinal change in clinical, radiologic and patient-reported outcomes compared by age cohort (ages 38–46 vs. 54–62 years) and by sex (slopes of change over preceding 2 years are compared)

	Female			Male			Female vs. Male		Adjusted interaction analysis
Cohort (years)	C1	C2	p	C1	C2	p	C1	C2
	38-46	54-62		38-46	54-62		p	p	Age Cohort*Sex
N	128	78		41	19
Clinical characteristics
EDSS	0.139	0.122	0.83	0.152	-0.066	0.11	0.876	0.201	0.22
MRI characteristics
BPF	-0.001	-0.001	0.7	-0.002	-0.004	0.3	0.336	0.193	0.48
T2 lesion volume	-0.002	0.025	0.34	0.019	-0.038	0.18	0.54	0.121	0.14
Patient- reported outcomes
CES- D	0.22	0.705	0.36	-0.146	0.056	0.82	0.526	0.456	0.74
MFIS	0.17	1.045	0.27	-0.475	0.806	0.37	0.549	0.846	0.86
SF- 36 *PCS*	-0.061	-0.349	0.5	0.196	1.111	0.26	0.628	0.052	0.16
SF- 36 *MCS*	-0.357	-1.304	0.17	0.259	-0.858	0.33	0.419	0.632	0.99

Legend: EDSS, expanded disability status scale, BPF, brain parenchymal fraction, CES-D, Center for Epidemiological Study, MFIS, Modified Fatigue Impact Scale.

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