Table 1 Clinical characteristics and genotypes in the 14 patients with OXC-induced MPE and in the 28 OXC-tolerant controls
OXC-induced MPE | ||||||||
|---|---|---|---|---|---|---|---|---|
ID No. | Gender | Phenotype | Initial-dose (mg) | Final-dose (mg) | Latency (d) | Concurrent drug | HLA-B 1502 | Four-digit allele |
1 | M | MPE | 300 | 600 | 12 | N | Negative | HLA-B*4001/4001 |
2 | F | MPE | 300 | 600 | 11 | N | Negative | HLA-B*1302/4601 |
3 | F | MPE | 300 | 450 | 16 | N | Negative | HLA-B*1302/1302 |
4 | M | MPE | 300 | 600 | 9 | N | Negative | HLA-B*1501/5101 |
5 | F | MPE | 300 | 450 | 15 | N | Negative | HLA-B*1501/1527 |
6 | M | MPE | 300 | 600 | 12 | N | Negative | HLA-B*1501/4403 |
7 | F | MPE | 300 | 900 | 16 | N | Negative | HLA-B*1501/1542 |
8 | M | MPE | 300 | 600 | 11 | N | Negative | HLA-B*4001/1558 |
9 | F | MPE | 300 | 900 | 17 | N | Negative | HLA-B*3802/4403 |
10 | F | MPE | 300 | 450 | 8 | N | Negative | HLA-B*5201/5301 |
11 | F | MPE | 300 | 600 | 10 | N | Negative | HLA-B*5502/5601 |
12 | F | MPE | 300 | 750 | 14 | N | positive | HLA-B*3802/1502 |
13 | M | MPE | 300 | 750 | 12 | N | Negative | HLA-B*1301/1301 |
14 | F | MPE | 300 | 600 | 9 | N | Negative | HLA-B*4402/3802 |
OXC-tolerant | ||||||||
ID No. | Gender | Phenotype | Initial-dose (mg) | Final-dose (mg) | Latency (d) | Concurrent drug | HLA-B 1502 | Four-digit allele |
15 | F | Tolerant | 300 | 900 | N | N | Negative | HLA-B*4801/3531 |
16 | F | Tolerant | 300 | 600 | N | N | Negative | HLA-B*4403/4804 |
17 | M | Tolerant | 300 | 600 | N | N | Negative | HLA-B*4001/5501 |
18 | M | Tolerant | 300 | 900 | N | N | Negative | HLA-B*3802/4403 |
19 | F | Tolerant | 300 | 900 | N | N | Negative | HLA-B*4403/4403 |
20 | M | Tolerant | 300 | 600 | N | N | Negative | HLA-B*3802/1302 |
21 | F | Tolerant | 300 | 600 | N | N | Negative | HLA-B*4801/3531 |
22 | M | Tolerant | 300 | 450 | N | N | Negative | HLA-B*4601/1511 |
23 | M | Tolerant | 300 | 600 | N | N | Negative | HLA-B*1501/4001 |
24 | F | Tolerant | 300 | 450 | N | N | Negative | HLA-B*1511/4801 |
25 | F | Tolerant | 300 | 600 | N | N | Negative | HLA-B*4403/5604 |
26 | F | Tolerant | 300 | 900 | N | N | Negative | HLA-B*1302/5801 |
27 | M | Tolerant | 300 | 900 | N | N | Negative | HLA-B*1302/0705 |
28 | F | Tolerant | 300 | 600 | N | N | Negative | HLA-B*3710/4701 |
29 | F | Tolerant | 300 | 600 | N | N | Negative | HLA-B*1302/1315 |
30 | F | Tolerant | 300 | 600 | N | N | Negative | HLA-B*1302/3901 |
31 | F | Tolerant | 300 | 900 | N | N | Negative | HLA-B*5102/3508 |
32 | M | Tolerant | 300 | 900 | N | N | Negative | HLA-B*5502/3801 |
33 | F | Tolerant | 300 | 450 | N | N | Negative | HLA-B*1501/1513 |
34 | F | Tolerant | 300 | 600 | N | N | Negative | HLA-B*1301/1301 |
35 | M | Tolerant | 300 | 600 | N | N | Negative | HLA-B*2705/5101 |
36 | M | Tolerant | 300 | 450 | N | N | Negative | HLA-B*4801/4801 |
37 | F | Tolerant | 300 | 600 | N | N | positive | HLA-B*1502/4001 |
38 | F | Tolerant | 300 | 750 | N | N | positive | HLA-B*5801/1502 |
39 | F | Tolerant | 300 | 900 | N | N | Negative | HLA-B*4001/4006 |
40 | M | Tolerant | 300 | 600 | N | N | positive | HLA-B*1502/5801 |
41 | M | Tolerant | 300 | 450 | N | N | positive | HLA-B*4601/1502 |
42 | F | Tolerant | 300 | 900 | N | N | positive | HLA-B*4601/1502 |