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Table 2 Frequencies of HLA-B alleles and their associations with OXC-induced MPE

From: The association between oxcarbazepine-induced maculopapular eruption and HLA-B alleles in a Northern Han Chinese population

 

Frequency

MPE cases compared with OXC-tolerant controls

MPE cases compared with normal population controls

Alleles

MPE a

OXC-tolerant controls b

Population controls c,d

OR (95% CI)

P

OR (95% CI)

P

0705

0/28 (0)

1/56 (1.8)

4/1236 c (0.4)

0.65 (0.03–16.45)

1.00

4.81 (0.25–91.38)

1.00

1301

2/28 (7.1)

2/56 (3.6)

44/1236 c (3.6)

2.08 (0.28–15.58)

0.86

2.08 (0.48–9.06)

0.62

1302

3/28 (10.7)

5/56 (8.9)

69/1236 c (5.5)

1.22 (0.27–5.54)

1.00

2.03 (0.60–6.89)

0.46

1315

0/28 (0)

1/56 (1.8)

–

0.65 (0.03–16.45)

1.00

–

–

1501

4/28 (14.3)

2/56 (3.6)

86/1236 c (7.0)

4.50 (0.77–26.27)

0.18

2.23 (0.76–6.57)

0.26

1502

1/28 (3.6)

5/56 (8.9)

29/1236 c (2.4)

0.38 (0.04–3.40)

0.65

1.54 (0.20–11.73)

0.49

1511

0/28 (0)

2/56 (3.6)

21/1236 c ( 1.7)

0.38 (0.02–8.24)

0.55

0.99 (0.06–16.78)

1.00

1513

0/28 (0)

1/56 (1.8)

1/1236 c (0.1)

0.65 (0.03–16.45)

1.00

14.45 (0.58–362.44)

1.00

1527

1/28 (3.6)

0/56 (0)

2/1236 c (0.2)

6.16 (0.24–156.27)

0.33

22.85 (2.01–259.72)

0.07

1542

1/28 (3.6)

0/56 (0)

0/210 d (0)

6.16 (0.24–156.27)

0.33

22.96 (0.91–577.76)

0.12

1558

1/28 (3.6)

0/56 (0)

2/1236 c (0.2)

6.16 (0.24–156.27)

0.33

22.85 (2.01–259.72)

0.07

2705

0/28 (0)

1/56 (1.8)

6/1236 c (0.5)

0.65 (0.03–16.45)

1.00

3.32 (0.18–60.38)

1.00

3508

0/28 (0)

1/56 (1.8)

1/1236 c (0.1)

0.65 (0.03–16.45)

1.00

14.45 (0.58–362.44)

1.00

3531

0/28 (0)

2/56 (3.6)

0/210 d (0)

0.38 (0.02–8.24)

0.55

–

–

3710

0/28 (0)

1/56 (1.8)

–

0.65 (0.03–16.45)

1.00

–

–

3801

0/28 (0)

1/56 (1.8)

8/1236 c (0.7)

0.65 (0.03–16.45)

1.00

2.54 (0.14–45.00)

1.00

3802

3/28 (10.7)

2/56 (3.6)

23/1236 c (1.9)

3.24 (0.51–20.63)

0.42

6.329 (1.783–22.460)

0.018 e

3901

0/28 (0)

1/56 (1.8)

23/1236 c (1.9)

0.65 (0.03–16.45)

1.00

0.91 (0.05–15.29)

1.00

4001

3/28 (10.7)

4/56 (7.1)

100/1236 c (8.1)

1.56 (0.32–7.51)

0.89

1.36 (0.41–4.59)

0.88

4006

0/28 (0)

1/56 (1.8)

39/1236 c (3.2)

0.65 (0.03–16.45)

1.00

0.53 (0.03–8.87)

1.00

4402

1/28 (3.6)

0/56 (0)

11/1236 c (0.9)

6.16 (0.24–156.27)

0.33

4.13 (0.51–33.09)

0.24

4403

2/28 (7.1)

5/56 (8.9)

32/1236 c (2.6)

0.79 (0.14–4.32)

1.00

2.89 (0.66–12.72)

0.17

4601

1/28 (3.6)

3/56 (5.4)

118/1236 c (9.6)

0.65 (0.07–6.59)

1.00

0.35 (0.05–2.61)

0.46

4701

0/28 (0)

1/56 (1.8)

0/210 d (0)

0.65 (0.03–16.45)

1.00

–

–

4801

0/28 (0)

5/56 (8.9)

24/1236 c (2)

0.16 (0.01–3.08)

0.25

0.87 (0.05–14.63)

1.00

4804

0/28 (0)

1/56 (1.8)

0/210 d (0)

0.65 (0.03–16.45)

1.00

–

–

5101

1/28 (3.6)

1/56 (1.8)

66/1236 c (5.4)

2.04 (0.12–33.83)

1.00

0.66 (0.09–4.91)

1.00

5102

0/28 (0)

1/56 (1.8)

6/1236 c (0.5)

0.65 (0.03–16.45)

1.00

3.32 (0.18–60.38)

1.00

5201

1/28 (3.6)

0/56 (0)

21/1236 c (1.9)

6.16 (0.24–156.27)

0.33

2.14 (0.28–16.51)

0.39

5301

1/28 (3.6)

0/56 (0)

0/210 d (0)

6.16 (0.24–156.27)

0.33

22.96 (0.91–577.76)

0.12

5501

0/28 (0)

1/56 (1.8)

7/1236 c (0.6)

0.65 (0.03–16.45)

1.00

2.88 (0.16–51.58)

1.00

5502

1/28 (3.6)

1/56 (1.8)

35/1236 c (2.9)

2.04 (0.12–33.83)

1.00

1.27 (0.17–9.62)

0.56

5601

1/28 (3.6)

0/56 (0)

2/1236 c (0.2)

6.16 (0.24–156.27)

0.33

22.85 (2.01–259.72)

0.07

5604

0/28 (0)

1/56 (2.5)

1/1236 c (0.1)

0.65 (0.03–16.45)

1.00

14.45 (0.58–362.44)

1.00

5801

0/28 (0)

3/56 (5.3)

74/1236 c (6)

0.27 (0.01–5.38)

0.55

0.27 (0.02–4.53 )

0.35

  1. a 2n = 28.
  2. b 2n = 56.
  3. c 2n = 1236, from a China Beijing Shijiazhuang Tianjin Han population of 618 persons (http://www.allelefrequencies.net).
  4. d 2n = 210, from a China North Han population of 105 persons (http://www.allelefrequencies.net). Note: The frequency of these alleles has not been reported by the former.
  5. OXC, oxcarbazepine; MPE, maculopapular eruption; OR, odds ratio; CI: confidence interval.
  6. e P < 0.05 (two-sided) was statistically significant.
  7. –, no data available.
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