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Table 1 Basal and final means of biochemical, hematological and biomarker variables

From: Adverse events during the titration phase of interferon-beta in remitting-relapsing multiple sclerosis are not predicted by body mass index nor by pharmacodynamic biomarkers

Variable

Basal mean (SD) [No. of Valid cases]

Final mean (SD) [No. of Valid cases]

p*

Pearson correlation (BMI)

Spearman correlation (BMI)

Haemoglobin (g/dL)

13.94 (1.16) [81]

13.64 (1.28) [81]

NS

-0.015

0.095

Hematocrit (%)

41.48 (3.50) [81]

40.56 (3.61) [81]

NS

-0.095

0.020

Blood sedimentation rate (mm)

12.31 (10.89) [58]

14.49 (11.65) [71]

NS

0.112

0.067

Leukocytes (1000/mm [3])

8.25 (3.14) [83]

5.67 (1.67) [81]

<0.01

-0.081

0.056

Granulocytes (1000/mm [3])

5.29 (2.88) [82]

3.20 (1.22) [81]

<0.01

-0.127

0.014

Lymphocytes (1000/mm [3])

2.32 (1.10) [83]

1.76 (0.61) [81]

<0.01

-0.060

0.106

Platelet count (1000/mm [3]

275.59 (81.21) [83]

211.39 (63.98) [81]

<0.01

0.078

0.158

Creatinine

0.78 (0.17) [82]

0.74 (0.15) [81]

0.02

-0.117

-0.091

sGOT (ALT)

17.50 (5.99) [80]

34.11 (39.75) [81]

<0.01

-0.091

-0.149

sGPT (AST)

23.34 (15.66) [80]

53.56 (98.87) [81]

<0.01

-0.149

-0.178

GGT

19.18 (11.23) [68]

36.34 (36.93) [73]

<0.01

-0.102

-0.008

Alkaline phosphatase

95.54 (46.27) [67]

101.24 (48.73) [75]

NS

-0.037

-0148

Bilirubin

0.60 (.36) [78]

0.53 (0.30) [81]

0.025

0.084

0.049

β2M

1.27 (0.23) [83]

1.84 (0.26) [83]

<0.01

-0.189

-0.259

OAS1

50.65 (45.04) [79]

183.75 (99.52) [83]

<0.01

0.003

-0.043

Np

1.46 (0.68) [83]

2.81 (0.81) [83]

<0.01

0.034

-0.043

  1. * Paired samples test for difference of means (2-tailed).