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Table 1 Effect of PPARGC1A rs3736265 on AO

From: A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort

  rs3736265 genotype P1 P2
  CC CT TT   
All      
N 1518 186 2   
HD CAG repeat size 44.7 (4.6) 44.7 (3.8) 46.0 (2.8) n.s. n.s.
non-HD CAG repeat size 18.5 (3.4) 18.5 (3.3) 19.0 (2.8) n.s. n.s
CAG-product3 828 (178) 831 (185) 870 (76) n.s. n.s.
Log AO4 1.641 (0.128) 1.627 (0.126) 1.601 (0.088) 0.0519 0.0170
AO5 43.75 42.36 39.9   
Men      
N 784 84 1   
HD CAG repeat size 44.8 (4.5) 44.5 (.2) 44.0 (0) n.s. n.s.
non-HD CAG repeat size 18.6 (3.5) 18.8 (3.5) 21.0 (0) n.s. n.s
CAG-product3 836 (185) 840 (176) 924 (0) n.s. n.s.
Log AO4 1.655 (0.128) 1.629 (0.126) 1.638 (0) 0.0164 0.0042
AO5 45.19 42.56 43.45   
Women      
N 734 102 1   
HD CAG repeat size 44.5 (4.7) 44.8 (4.2) 48.0 (0) n.s. n.s.
non-HD CAG repeat size 18.4 (3.4) 18.3 (3.2) 17.0 (0) n.s. n.s.
CAG-product3 818 (170) 823 (192) 816 n.s. n.s.
Log AO4 1.626 (0.128) 1.622 (0.127) 1.568 (0) 0.6732 0.5705
AO5 42.27 41.88 36.98   
  1. Data are means (SD); P1, additive model; P2, dominant model; ANOVA; 3product of the CAG sizes in the two alleles 4adjusted for HD CAG and non-HD CAG sizes and their products. 5ANOVA was used and the p-values refer to the log-transformed age-at-onset. The age-at-onset is only shown to give an estimate of the effects that is easier to interpret. All genotype distributions are in HW equilibrium, MAF in entire population 0.0554.