Figure 2

Cost-effectiveness of early intervention with a modest symptomatic treatment in the nine years prior to standard detection and treatment. Panel A net benefit; B Gain in quality-adjusted life years (QALYs); C incremental costs. Symptomatic effects = 1 MMSE point, efficacy reduces linearly over 3 years. Costs calculated over a 10-year horizon. Mean cohort age at entry 75 years.