|
Global fatigue severity (GFS) subscale of the FAI
(potential range 1 to 7, high scores indicate more fatigue)
|
|
FACETS mean (SD)
|
5.60 (0.98)
|
5.48 (0.92)
|
5.26 (1.03)
|
5.32 (1.00)
|
|
CLP mean (SD)
|
5.61 (1.09)
|
5.55 (1.17)
|
5.66 (0.93)
|
5.70 (1.01)
|
|
Mean difference in change from baseline [95% CI]
|
-
|
−0.03 (−0.33 to 0.28)
|
−0.36 (−0.63 to −0.08)
|
−0.30 (−0.61 to 0.01)
|
|
p value
|
-
|
0.86
|
0.01
|
0.06
|
|
Std effect size
|
-
|
−0.03
|
−0.35
|
−0.29
|
|
Multiple Sclerosis Impact Scale-29 (MSIS-29)
(potential range 0 to 100, high scores indicate more impact)
|
|
FACETS mean (SD)
|
49.6 (19.1)
|
47.3 (18.2)
|
44.9 (19.2)
|
46.2 (19.1)
|
|
CLP mean (SD)
|
43.9 (17.6)
|
42.2 (18.4)
|
43.0 (17.3)
|
47.2 (17.4)
|
|
Mean difference in change from baseline [95% CI]
|
-
|
1.44 (−2.36 to 5.24)
|
−1.56 (−6.45 to 3.34)
|
−4.34 (−8.61 to −0.08)
|
|
p value
|
-
|
0.46
|
0.53
|
0.046
|
|
Std effect size
|
-
|
0.08
|
−0.08
|
−0.24
|
|
MS Fatigue Self-Efficacy scale (MS-FSE)
(potential range 10 to 100, high scores indicate more certainty in controlling fatigue
|
|
FACETS mean (SD)
|
45 (17)
|
57 (17)
|
56 (19)
|
56 (16)
|
|
CLP mean (SD)
|
49 (16)
|
50 (17)
|
53 (17)
|
52 (17)
|
|
Mean difference in change from baseline [95% CI]
|
-
|
9 (4 to 14)
|
6 (0 to 12)
|
6 (−1 to 12)
|
|
p value
|
-
|
0.001
|
0.048
|
0.09
|
|
Std effect size
|
-
|
0.54
|
0.36
|
0.34
|
|
Statistically significant secondary outcome measures
|
|
Vitality subscale of the SF-36
(potential range 0 to 100, high scores indicate higher quality of life)
|
|
FACETS mean (SD)
|
32.0 (16.8)
|
35.6 (19.4)
|
37.4 (20.3)
|
37.70 (18.75)
|
|
CLP mean (SD)
|
35.1 (19.7)
|
33.4 (16.8)
|
34.4 (17.30
|
32.43 (17.69)
|
|
Mean difference in change from baseline [95% CI]
|
-
|
4.42 (−1.22 to 10.06)
|
6.38 (0.45 to 12.32)
|
6.64 (0.84 to 12.44)
|
|
p value
|
-
|
0.12
|
0.04
|
0.03
|
|
Std effect size
|
-
|
0.24
|
0.35
|
0.37
|
|
Multiple Sclerosis Impact Scale-29 (MSIS-29) - Physical subscale
(potential range 0 to100, high scores indicate more impact)
|
|
FACETS mean (SD)
|
51.4 (21.4)
|
48.8 (19.7)
|
47.0 (21.3)
|
47.4 (21.0)
|
|
CLP mean (SD)
|
46.6 (20.3)
|
44.9 (20.5)
|
46.5 (19.8)
|
50.5 (20.1)
|
|
Mean difference in change from baseline [95% CI]
|
-
|
1.39 (−2.87 to 5.65)
|
−0.81 (−5.91 to 4.28)
|
−4.74 (−9.40 to −0.08)
|
|
p value
|
-
|
0.52
|
0.75
|
0.046
|
|
Std effect size
|
-
|
0.07
|
−0.04
|
−0.23
|
