Potential biomarkers relating pathological proteins, neuroinflammatory factors and free radicals in PD patients with cognitive impairment: a cross-sectional study

Table 2 Comparisons of the levels of pathological proteins in CSF among control, PD-NCI and PD-CI groups

Pathological proteins	Control group (31 cases)	PD-NCI group (26 cases)	PD-CI group (36 cases)	P¹	P²	P³
T-tau (pg/ml)	39.209 (10.274 ~ 141.454)	95.991 (23.105 ~ 125.394)	135.167 (41.261 ~ 175.683)	0.295	0.004	0.016
P-tau (S199) (pg/ml)	3.426 ± 0.561	6.544 ± 1.641	6.491 ± 1.579	0.000	0.000	1.000
P-tau (S396) (pg/ml)	49.335 ± 26.215	71.059 ± 22.399	76.454 ± 33.340	0.037	0.001	0.607
P-tau (T181) (pg/ml)	40.138 (30.722 ~ 53.644)	77.185 (49.271 ~ 95.730)	61.557 (55.461 ~ 84.649)	0.001	0.000	0.943
P-tau (T231) (pg/ml)	62.948 (46.241 ~ 80.793)	91.580 (87.163 ~ 148.387)	101.746 (71.852 ~ 180.582)	0.001	0.000	0.749
Aβ1-42 (ng/ml)	0.402 ± 0.082	0.432 ± 0.103	0.416 ± 0.113	0.273	0.590	0.535

P¹: Control group vs. PD-NCI group; P²: Control group vs. PD-CI group, P³: PD-NCI group vs. PD-CI group.

ISSN: 1471-2377