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Table 1 Characteristics of the study sample

From: Paternal therapy with disease modifying drugs in multiple sclerosis and pregnancy outcomes: a prospective observational multicentric study

 

Total sample (#78)

Exposed to DMD (#45)

Not-exposed (#33)

p

Variables related to MS father

Age, mean (SD) years (#78)

34.8 (4.8)

35.4 (5.3)

33.9 (3.9)

0.476*

Education, mean (SD) years (#62)

13.4 (3.5)

13.2 (3.3)

13.8 (4.0)

0.548*

Age at onset, mean (SD) years (#75)

26.5(6.8)

27.0 (7.2)

25.7 (6.2)

0.352*

Disease duration, mean (SD) years (#74)

8.4 (5.9)

8.5 (6.0)

8.3 (5.9)

0.812*

Smokers # (%) (#78)

26 (33.3)

14 (31.1)

12 (36.4)

0.627**

Alcohol # (%) (#78)

14 (17.9)

10 (22.2)

4 (12.1)

0.251**

Variables related to pregnancy and fetal outcomes

Drug and toxin exposure # (%) (78)

-

-

-

-

Smoking exposure # (%) (78)

5 (6.4)

2 (4.4)

3 (9.1)

0.645§

Alcohol exposure # (%) (#78)

-

-

-

-

Gestational age (weeks) (#72)

38.9 (3.8)

39.0 (2.1)

38.7 (5.2)

0.513*

Preterm delivery # (%) (#72)

10 (13.9)

7 (17.1)

3 (9.7)

0.499§

Caesarean delivery # (%) (#75)

24 (32.0)

15 (34.1)

9 (29.0)

0.644**

Epidural analgesia # (%) (#75)

16 (21.3)

10 (22.7)

6 (19.4)

0.726**

Gender of the baby male/female (#75)

36/39

21/23

15/16

0.955**

Birth-weight mean (SD) gr (#75)

3301.3 (454.9)

3282.3 (445.5)

3328.4 (474.1)

0.821*

Birth-length mean (SD) cm (#67)

50.1 (2.2)

49.9 (2.3)

50.2 (2.1)

0.649*

  1. DMD: Disease Modifying Drug; SD: Standard Deviation.
  2. *Mann Whitney U-test; ** χ 2 test; §Fisher’s exact χ 2 test.
  3. p values related to the exposed versus unexposed group comparison.