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Table 1 Conservation analysis of private variants and contiguous amino acid residues

From: Association of the mtDNA m.4171C>A/MT-ND1 mutation with both optic neuropathy and bilateral brainstem lesions

Mutation m.4705T>C m.5263C>T m.14180T>C
Locus MT-ND2 MT-ND2 MT-ND6
AA change p.M79T p.A265V p.Y165C
Conservation (%)
Eukaryotes 25 (n = 161) 48 (n = 161) 36 (n = 124)
Vertebrates 3 (n = 126) 57 (n = 126) 54 (n = 83)
Mammals 41 (n = 95) 75 (n = 95) 26 (n = 43)
Prediction
Polyphen 2 Benign Benign Probably damaging
Provean Deleterious Neutral Deleterious
Contiguous amino acid conservation
Interval (−10/+10) 69-89 255-275 155-174
Local conservation (%) 68 83 69
Global conservation (%) 62 62 52
Nearest invariant position (−/+) −1/+2 −1/+1 −1/+4