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Table 2 Five year prevalence estimates for different measures (20002005) for musculoskeletal, cardiovascular and mental disorders among MS patients and the general population, with incidence rates (IRs) for DP per 100 000 person-years and adjusted odds ratios (ORs) with 95% confidence intervals (CIs)

From: Co-morbidities increase the risk of disability pension among MS patients: a population-based nationwide cohort study

  MS -patients General Population MS patients vs. General population (All)d MS patients vs. General population (at risk for DP)d
All (n = 10 791) At risk for DP (n = 4 519) All (n = 5 618 191) At risk for DP (n = 4 972 174)
Model 1 b % % IRs % % IRs Adj ORs CI 95% Adj ORs CI 95%
Musculoskeletal disorders           
Yes 43.5 33.8 88.2 22.1 19.7 15.1 2.21 (2.11-2.28) 1.91 (1.79-2.03)
No    56.4    3.5     
Cardiovascular disorders           
Yes 24.8 15.4 90.5 14.6 12.4 15.7 1.42 (1.36-1.49) 1.34 (1.23-1.46)
No    62.6    4.4     
Mental disorders           
Yes 43.5 29.4 109.6 15.5 12.1 25.2 3.37 (3.24-3.50) 2.59 (2.43-2.77)
No    51.1    3.2     
Model 2 a           
Musculoskeletal disorders           
Yes 22.0 18.7 81.9 15.6 13.6 17.8 1.25 (1.19-1.31) 1.37 (1.27-1.48)
No    63.3    3.9     
Cardiovascular disorders           
Yes 12.2 8.0 85.1 6.9 5.5 19.6 1.47 (1.39-1.57) 1.55 (1.39-1.67)
No    65.1    5.0     
Mental disorders           
Yes 11.7 10.3 99.8 8.9 7.1 27.7 1.20 (1.13-1.27) 1.31 (1.19-1.44)
No    62.8    4.2     
Model 3 c           
Musculoskeletal disorders (exl. ATC: M01, M03)           
Yes 24.1 19.7 82.0 16.5 14.3 17.7 1.31 (1.26-1.37) 1.40 (1.30-1.50)
No    63.0    3.8     
Mental disorders (exl. ATC:N06AB, N05c)           
Yes 35.8 22.1 110.1 13.9 10.7 26.0 2.80 (2.69-2.91) 2.03 (1.89-2.18)
No    55.8    3.4     
  1. aPrevalence estimates are based on sick-leave (MiDAS) and on in- and out-patient ICD-10 diagnoses (PAR); M00-M99, I00-I99 and F00-F99.
  2. bPrevalence estimates are based on sick-leave (MiDAS) and on in- and out-patient ICD-10 diagnoses (PAR); M00-M99, I00-I99 and F00-F99, and the following ATC-codes (PDR); M01-M09. C01-C10 and N05-N06.
  3. cPrevalence estimates are based on the same criteria as the model 1, except that hypnotics and sedatives (ATC: N05C), centrally acting sympathomimetics (N06BA) anesthetics (M01), and muscle relaxants (M03) are excluded from the case definition.
  4. dAll analyses are adjusted for gender and age-groups. In the models the general population is coded as the reference category, i.e. ORs >1 indicate that MS-patients are more likely to have a particular type of disorder.