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Table 4 Musculoskeletal, cardiovascular, and mental disorderssynergistic influence on DP in a five-year follow up, presented as hazard ratios (HRs), attributable proportion due to interaction (AP), and synergy index (SI)a

From: Co-morbidities increase the risk of disability pension among MS patients: a population-based nationwide cohort study

Models   HRs (95% CI) AP % (95% CI) SI (95% CI)
Model 1 No musculoskeletal disorder and no MS 1   
  Musculoskeletal disorder (only) 3.46 (3.43-3.50)   
  MS (only) 16.74 (15.36-18.25)   
  Musculoskeletal disorder and MS 27.27 (25.36-29.34) 29.6 (22.3-34.9) 1.44 (1.33-1.56)
Model 1 No cardiovascular disorder and no MS 1   
  Cardiovascular disorder (only) 2.51 (2.48-2.54)   
  MS (only) 15.13 (14.18-16.15)   
  Cardiovascular disorders and MS 17.04 (15.29-18.99) 2.3 (-1-14.2) 1.03 (0.90-1.17)
Model 1 No mental disorder and no MS 1   
  Mental disorder (only) 8.48 (8.38-8.58)   
  MS (only) 8.66 (7.85-9.55)   
  Mental disorder and MS 30.99 (28.56-33.64) 48.0 (44.1-51.8) 1.98 (1.84-2.14)
  1. aThe cardiovascular, musculoskeletal, and mental disorder variables are based on sick-leave (MiDAS) and in- and out-patient ICD-10 diagnoses (PAR); M00-M99, I00-I99 and F00-F99, and the following ATC-codes (PDR); M01-M09, C01-C10 and N05-N06. Exposure variables and cohabiting status are modeled as time-dependent covariates. The models are also adjusted for gender, age, educational level, country of birth, type of living area, and geographic region.
  2. All estimates are supplemented with 95% confidence intervals (95% CI).