Effect of TTP488 in patients with mild to moderate Alzheimer’s disease

BMC Neurology

Table 3 TTP488 median and mean trough concentrations associated with the 5 mg/day and 20 mg/day dose groups

	TTP488 dose group	TTP488 mean concentration^a	TTP488 median concentration^b	95% confidence interval of the mean
		(ng/mL)	(ng/mL)
Median of subjects’ trough values	5 mg/day (n = 131)	13.02	12.25	[11.74, 14.31]
Median of subjects’ trough values	20 mg/day (n = 134)	68.57	64.58	[63.46, 73.69]
Mean of subjects’ trough values	5 mg/day (n = 131)	16.22	14.90	[14.59, 17.85]
	20 mg/day (n = 134)	83.75	75.05	[77.40, 90.10]

Mean and median concentration across the measured timepoints was determined for each subject. Descriptive statistics (mean, median) subsequently provided for each measure.
^aMean TTP488 concentration across the 18 months, or available time points, for each individual subject. Each subject contributes a single value.
^bMedian TTP488 concentration across the 18 months, or available time points, for each individual subject. Each subject contributes a single value.

ISSN: 1471-2377