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Table 3 TTP488 median and mean trough concentrations associated with the 5 mg/day and 20 mg/day dose groups

From: Effect of TTP488 in patients with mild to moderate Alzheimer’s disease

  TTP488 dose group TTP488 mean concentrationa TTP488 median concentrationb 95% confidence interval of the mean
   (ng/mL) (ng/mL)  
Median of subjects’ trough values 5 mg/day (n = 131) 13.02 12.25 [11.74, 14.31]
20 mg/day (n = 134) 68.57 64.58 [63.46, 73.69]
Mean of subjects’ trough values 5 mg/day (n = 131) 16.22 14.90 [14.59, 17.85]
  20 mg/day (n = 134) 83.75 75.05 [77.40, 90.10]
  1. Mean and median concentration across the measured timepoints was determined for each subject. Descriptive statistics (mean, median) subsequently provided for each measure.
  2. aMean TTP488 concentration across the 18 months, or available time points, for each individual subject. Each subject contributes a single value.
  3. bMedian TTP488 concentration across the 18 months, or available time points, for each individual subject. Each subject contributes a single value.