Changes of liver enzymes and bilirubin during ischemic stroke: mechanisms and possible significance

BMC Neurology

Table 2 Time course of liver enzymes, bilirubin, blood counts and C-reactive protein

Variable	Normal range	N	Admission	7th day	P
GOT (U/l)	<38	138	19 [14-24]	22 [16–30]	<0.001
GPT (U/l)	<41	140	15 [11-21]	20 [13–33.5]	<0.001
γGT (U/l)	<61	138	22 [15–32]	26 [19–42]	<0.001
ALP (U/l)	<130	133	76 [59–108]	75 [62–106]	0.48
Unconjugated bilirubin (mg/dl)	<0.80	119	0.43 [0.31-0.64]	0.33 [0.23-0.43]	<0.001
Direct bilirubin (mg/dl)	<0.30	119	0.26 [0.19-0.37]	0.25 [0.18-0.33]	0.13
Erythrocytes (n/10⁶/mmc)	4.50-6.10	141	4.89 ± 0.67	4.72 ± 0.65	<0.001
Haemoglobin (g/dl)	13.0-16.5	142	13.6 ± 1.9	13.1 ± 2.2	<0.001
WBC (n/10³/mmc)	4.20-9.00	136	8.71 [6.95-10.41]	7.76 [6.42-9.88]	0.002
Platelets (n/10³/mmc)	150-380	138	224.8 ± 77.8	240.7 ± 90.6	<0.001
CRP (mg/dl)	<0.80	118	0.80 [0.27-3.58]	1.67 [0.36-4.38]	0.03

Values for admission and 7th day are medians [25th-75th percentile] or means ± SD.
ALP = Alkaline phosphatase, CRP = C-reactive protein, GOT = Glutamate oxaloacetate transaminase, GPT = glutamate piruvate transaminase, γGT = gamma glutamyl transferase, WBC = white blood cells.

ISSN: 1471-2377