Fingolimod in a patient with heart failure on the background of pulmonary arterial hypertension and coronary artery disease

Table 2 Parameter of systemic circulation during passive orthostatic tilt test before and after fingolimod application

	Pre-FTY baseline			2 h post-FTY			4 h post-FTY			6 h post-FTY			3 month follow-up			9 month follow-up
	→	↑	→	→	↑	→	→	↑	→	→	↑	→	→	↑	→	→	↑	→
HR [bpm]	74	84	80	70	73	66	61	64	59	74	76	74	65	70	65	60	64	62
Psyst [mmHg]	143	130	156	123	108	129	134	114	133	127	118	134	156	126	131	149	127	136
Pdiast [mmHg]	85	82	92	65	65	72	71	67	72	68	70	75	74	72	71	77	75	77
TPR [mmHg *s/ml]	1.43	1.55	1.5	0.68	0.76	0.83	0.92	0.86	0.9	0.69	0.88	0.85	0.81	1.06	0.93	1.1	1.41	1.23
CO [lpm]	3.9	3.5	4.3	8.4	5.9	6.9	6.7	6.3	6.5	7.9	6.1	7.1	7.4	4.9	6.2	5.9	4.5	5.1
SV \|ml]	50	43	54	119	83	67	106	97	116	109	78	103	116	72	96	102	70	83
E/I		1.16			1.13			1.14			1.16			1.06			1.09

FTY, Fingolimod. → lying position; ↑ tilted position. Reference values: HR: 60–100 bpm; Psyst, systolic blood pressure: 100–140 mmHg; Pdiast, diastolic blood pressure: 60–90 mmHg; TPR, total peripheral resistance: 0.6-1.3 mmHg*s/ml; CO, cardiac output: 4–8 lpm; SV, stroke volume: 55–100 ml; E/I: > 1.11.

ISSN: 1471-2377