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Table 2 Ordinal logistic regression analysis for the association of renal indicators and cerebral microbleeds

From: Cystatin C, a novel indicator of renal function, reflects severity of cerebral microbleeds

      Model1    Model2      
Variables N Unadjusted OR 95% CI P Adjusted OR 95% CI p Adjusted OR 95% CI p Adjusted OR 95% CI p
Age   1.02 1.01-1.04 <0.01 1.02 1.02-1.04 <0.01 1.01 1.00-1.03 0.07 1.02 1.01-1.04 0.02
Male   1.08 0.65-1.31 0.66 1.36 0.73-1.36 0.76 1.36 0.91-2.03 0.13 1.31 0.87-1.31 0.20
Hypertension   1.74 1.24-2.44 <0.01 1.43 1.05-2.18 0.03 1.51 1.05-2.19 0.03 1.53 1.06-2.23 0.02
Diabetes   1.19 0.82-1.72 0.36 0.85 0.57-1.28 0.45 1.23 0.74-1.68 0.59 1.18 0.78-1.78 0.44
Dyslipidemia   1.35 0.51-1.08 0.12 0.68 0.45-1.02 0.06 1.22 1.00-2.19 0.05 1.49 1.00-2.22 0.05
Heart disease   1.15 0.70-1.70 0.48 1.05 0.66-1.66 0.82 1.05 0.70-1.60 0.80 1.00 0.65-1.52 1.00
Smoking   1.62 1.12-2.34 0.01 1.35 0.86-2.13 0.05 1.91 1.25-2.92 <0.01 1.52 1.01-2.28 <0.01
Anticoagulant or thrombotics   2.26 1.53-2,26 <0.01 1.72 1.08-2.72 0.02 1.51 1.00-2.29 0.05 1.48 0.98-2.25 0.07
Total cholesterol   1.07 0.91-1.26 0.42 1.01 0.81-1.01 0.43 1.01 0.85-1.21 0.89 1.03 0.87-1.23 0.72
WML*              
Confluent   6.24 3.96-9.83 <0.01 4.08 2.37-7.02 <0.01 4.82 2.98-7.80 <0.01 4.56 2.80-7.41 <0.01
Early confluent   3.92 2.47-6.22 <0.01 2.66 1.60-4.41 <0.01 2.72 1.74-4.25 <0.01 2.62 1.67-4.12 <0.01
Puctate   1.82 1.06-3.14 0.03 1.31 0.72-2.39 0.38 1.57 0.91-2.70 0.11 1.45 0.83-2.51 0.19
Normal   ref    ref       ref   
p for trend     <0.01    <0.01       <0.01
Quartiles of cystatin C              
 Q4(≥66.7) 168 2.19 1.40-3.40 <0.01 1.90 1.07-3.37 0.02     1.88 1.05-3.38 0.03
 Q3(54.7-66.7) 173 1.57 0.92-2.46 0.10 1.31 0.45-1.28 0.35     1.24 0.74-2.08 0.42
 Q2(47.2-54.7) 162 0.98 0.61-1.58 0.16 1.54 0.85-2.80 0.16     0.83 0.49-1.41 0.49
 Q1(≤47.2), ref 180             
p for trend     <0.01    <0.01       <0.01
Quartiles of eGFR*              
 Q4(≤66.1) 171 2.26 1.42-3.62 <0.01     1.82 0.38-4.00 0.72 1.28 0.38-4.36 0.70
 Q3(66.1-78.8) 175 1.23 0.50-1.33 0.41     1.44 0.95-3.99 0.67 0.78 0.35-1.70 0.93
 Q2(78.8-94.7) 164 1.18 0.50-1.40 0.51     1.33 0.70-2.11 0.50 1.11 0.61-2.03 1.11
 Q1(≥94.7),ref 173             
p for trend     <0.01       <0.01    0.51
  1. *WML; white matter lesions, eGFR; estimated glomerular filtration rate.
  2. †Model 1: quartiles of estimated GFR and cystatin C were analyzed separately in the individual ordinal logistic regression model.
  3. ‡Model 2: quartiles of estimated GFR and cystatin C were analyzed together in the same logistic regression model.
  4. Model 1 and model 2 were adjusted for covariates; age, sex, total cholesterol, diabetes, hypertension, dyslipidemia, previous heart disease, smoking, previous anti thrombotic or anticoagulant use, and white matter lesions.