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Table 2 Ordinal logistic regression analysis for the association of renal indicators and cerebral microbleeds

From: Cystatin C, a novel indicator of renal function, reflects severity of cerebral microbleeds

     

Model1†

  

Model2‡

     

Variables

N

Unadjusted OR

95% CI

P

Adjusted OR

95% CI

p

Adjusted OR

95% CI

p

Adjusted OR

95% CI

p

Age

 

1.02

1.01-1.04

<0.01

1.02

1.02-1.04

<0.01

1.01

1.00-1.03

0.07

1.02

1.01-1.04

0.02

Male

 

1.08

0.65-1.31

0.66

1.36

0.73-1.36

0.76

1.36

0.91-2.03

0.13

1.31

0.87-1.31

0.20

Hypertension

 

1.74

1.24-2.44

<0.01

1.43

1.05-2.18

0.03

1.51

1.05-2.19

0.03

1.53

1.06-2.23

0.02

Diabetes

 

1.19

0.82-1.72

0.36

0.85

0.57-1.28

0.45

1.23

0.74-1.68

0.59

1.18

0.78-1.78

0.44

Dyslipidemia

 

1.35

0.51-1.08

0.12

0.68

0.45-1.02

0.06

1.22

1.00-2.19

0.05

1.49

1.00-2.22

0.05

Heart disease

 

1.15

0.70-1.70

0.48

1.05

0.66-1.66

0.82

1.05

0.70-1.60

0.80

1.00

0.65-1.52

1.00

Smoking

 

1.62

1.12-2.34

0.01

1.35

0.86-2.13

0.05

1.91

1.25-2.92

<0.01

1.52

1.01-2.28

<0.01

Anticoagulant or thrombotics

 

2.26

1.53-2,26

<0.01

1.72

1.08-2.72

0.02

1.51

1.00-2.29

0.05

1.48

0.98-2.25

0.07

Total cholesterol

 

1.07

0.91-1.26

0.42

1.01

0.81-1.01

0.43

1.01

0.85-1.21

0.89

1.03

0.87-1.23

0.72

WML*

             

Confluent

 

6.24

3.96-9.83

<0.01

4.08

2.37-7.02

<0.01

4.82

2.98-7.80

<0.01

4.56

2.80-7.41

<0.01

Early confluent

 

3.92

2.47-6.22

<0.01

2.66

1.60-4.41

<0.01

2.72

1.74-4.25

<0.01

2.62

1.67-4.12

<0.01

Puctate

 

1.82

1.06-3.14

0.03

1.31

0.72-2.39

0.38

1.57

0.91-2.70

0.11

1.45

0.83-2.51

0.19

Normal

 

ref

  

ref

     

ref

  

p for trend

   

<0.01

  

<0.01

     

<0.01

Quartiles of cystatin C

             

 Q4(≥66.7)

168

2.19

1.40-3.40

<0.01

1.90

1.07-3.37

0.02

   

1.88

1.05-3.38

0.03

 Q3(54.7-66.7)

173

1.57

0.92-2.46

0.10

1.31

0.45-1.28

0.35

   

1.24

0.74-2.08

0.42

 Q2(47.2-54.7)

162

0.98

0.61-1.58

0.16

1.54

0.85-2.80

0.16

   

0.83

0.49-1.41

0.49

 Q1(≤47.2), ref

180

            

 p for trend

   

<0.01

  

<0.01

     

<0.01

Quartiles of eGFR*

             

 Q4(≤66.1)

171

2.26

1.42-3.62

<0.01

   

1.82

0.38-4.00

0.72

1.28

0.38-4.36

0.70

 Q3(66.1-78.8)

175

1.23

0.50-1.33

0.41

   

1.44

0.95-3.99

0.67

0.78

0.35-1.70

0.93

 Q2(78.8-94.7)

164

1.18

0.50-1.40

0.51

   

1.33

0.70-2.11

0.50

1.11

0.61-2.03

1.11

 Q1(≥94.7),ref

173

            

 p for trend

   

<0.01

     

<0.01

  

0.51

  1. *WML; white matter lesions, eGFR; estimated glomerular filtration rate.
  2. †Model 1: quartiles of estimated GFR and cystatin C were analyzed separately in the individual ordinal logistic regression model.
  3. ‡Model 2: quartiles of estimated GFR and cystatin C were analyzed together in the same logistic regression model.
  4. Model 1 and model 2 were adjusted for covariates; age, sex, total cholesterol, diabetes, hypertension, dyslipidemia, previous heart disease, smoking, previous anti thrombotic or anticoagulant use, and white matter lesions.
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BMC Neurology

ISSN: 1471-2377

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