From: Cystatin C, a novel indicator of renal function, reflects severity of cerebral microbleeds
 |  |  |  |  | Model1†|  |  | Model2‡ |  |  |  |  |  |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variables | N | Unadjusted OR | 95% CI | P | Adjusted OR | 95% CI | p | Adjusted OR | 95% CI | p | Adjusted OR | 95% CI | p |
Age, per year | Â | 1.02 | 1.01-1.04 | <0.01 | 1.02 | 1.02-1.04 | <0.01 | 1.02 | 1.00-1.04 | 0.06 | 1.01 | 1.01-1.05 | 0.01 |
Male | Â | 1.08 | 0.65-1.31 | 0.66 | 1.36 | 0.73-1.36 | 0.76 | 1.39 | 0.87-2.22 | 0.17 | 1.31 | 0.86-2.12 | 0.27 |
Hypertension | Â | 1.74 | 1.24-2.44 | <0.01 | 1.43 | 1.05-2.18 | 0.03 | 1.77 | 1.14-2.78 | <0.01 | 1.83 | 1.17-2.86 | <0.01 |
Diabetes | Â | 1.19 | 0.82-1.72 | 0.36 | 0.85 | 0.57-1.28 | 0.45 | 1.04 | 0.64-1.68 | 0.88 | 1.10 | 0.68-1.79 | 0.70 |
Dyslipidemia | Â | 1.35 | 0.51-1.08 | 0.12 | 0.68 | 0.45-1.02 | 0.06 | 1.72 | 1.08-2.73 | 0.02 | 1.76 | 1.10-2.82 | 0.02 |
Heart disease | Â | 1.15 | 0.70-1.70 | 0.48 | 1.05 | 0.66-1.66 | 0.82 | 1.03 | 0.63-1.67 | 0.91 | 1.06 | 0.65-1.74 | 0.81 |
Smoking | Â | 1.62 | 1.12-2.34 | 0.01 | 1.35 | 0.86-2.13 | 0.05 | 1.22 | 0.76-1.96 | 0.41 | 1.26 | 0.78-2.04 | 0.35 |
Anticoagulant or thrombotics | Â | 2.26 | 1.53-2,26 | <0.01 | 1.72 | 1.08-2.72 | 0.02 | 1.67 | 1.01-2.76 | 0.05 | 1.63 | 0.98-2.70 | 0.26 |
Total cholesterol, per mmol/L | Â | 1.07 | 0.91-1.26 | 0.42 | 1.01 | 0.81-1.01 | 0.43 | 1.01 | 0.83-1.23 | 0.93 | 1.05 | 0.86-1.28 | 0.27 |
WML* | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Confluent | Â | 6.24 | 3.96-9.83 | <0.01 | 4.08 | 2.37-7.02 | <0.01 | 4.87 | 2.78-8.52 | <0.01 | 4.56 | 2.59-8.03 | <0.01 |
Early confluent | Â | 3.92 | 2.47-6.22 | <0.01 | 2.66 | 1.60-4.41 | <0.01 | 2.67 | 1.57-4.53 | <0.01 | 2.54 | 1.49-4.34 | <0.01 |
Puctate | Â | 1.82 | 1.06-3.14 | 0.03 | 1.31 | 0.72-2.39 | 0.38 | 1.60 | 0.85-3.01 | 0.15 | .1.49 | 0.79-2.83 | 0.22 |
Normal,ref | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
p for trend | Â | Â | Â | <0.01 | Â | Â | Â | Â | Â | <0.01 | Â | Â | <0.01 |
Quartiles of cystatin C | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Q4(≥66.7) | 168 | 2.19 | 1.40-3.40 | <0.01 | 1.90 | 1.07-3.37 | 0.02 |  |  |  | 2.06 | 1.07-3.94 | 0.03 |
Q3(54.7-66.7) | 173 | 1.57 | 0.92-2.46 | 0.10 | 1.31 | 0.45-1.28 | 0.35 | Â | Â | Â | 2.20 | 1.18-4.09 | 0.01 |
Q2(47.2-54.7) | 162 | 0.98 | 0.61-1.58 | 0.16 | 1.54 | 0.85-2.80 | 0.16 | Â | Â | Â | 1.36 | 0.78-2.36 | 0.27 |
Q1(≤47.2), ref | 180 |  |  |  |  |  |  |  |  |  |  |  |  |
p for trend | Â | Â | Â | <0.01 | Â | Â | <0.01 | Â | Â | Â | Â | Â | <0.01 |
Quartiles of Alb/Cr*, | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Q4(≥100.8) | 160 | 1.52 | 0.87-2.66 | 0.14 |  |  |  | 1.61 | 0.88-2.95 | 0.13 | 1.34 | 0.71-1.43 | 0.36 |
Q3(24.0-.100.8) | 136 | 1.20 | 0.70-2.06 | 0.51 | Â | Â | Â | 1.32 | 0.75-2.29 | 0.33 | 1.28 | 0.73-1.48 | 0.38 |
Q2(11.0-24.0) | 217 | 0.97 | 0.52-1.80 | 0.91 | Â | Â | Â | 1.09 | 0.59-2.03 | 0.78 | 0.86 | 0.53-1.61 | 0.76 |
Q1(≤11.0),ref | 170 |  |  |  |  |  |  |  |  |  |  |  |  |
p for trend | Â | Â | Â | 0.10 | Â | Â | Â | Â | Â | 0.16 | Â | Â | 0.20 |