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Table 3 Ordinal logistic regression analysis for the association of renal indicators and cerebral microbleeds

From: Cystatin C, a novel indicator of renal function, reflects severity of cerebral microbleeds

      Model1    Model2      
Variables N Unadjusted OR 95% CI P Adjusted OR 95% CI p Adjusted OR 95% CI p Adjusted OR 95% CI p
Age, per year   1.02 1.01-1.04 <0.01 1.02 1.02-1.04 <0.01 1.02 1.00-1.04 0.06 1.01 1.01-1.05 0.01
Male   1.08 0.65-1.31 0.66 1.36 0.73-1.36 0.76 1.39 0.87-2.22 0.17 1.31 0.86-2.12 0.27
Hypertension   1.74 1.24-2.44 <0.01 1.43 1.05-2.18 0.03 1.77 1.14-2.78 <0.01 1.83 1.17-2.86 <0.01
Diabetes   1.19 0.82-1.72 0.36 0.85 0.57-1.28 0.45 1.04 0.64-1.68 0.88 1.10 0.68-1.79 0.70
Dyslipidemia   1.35 0.51-1.08 0.12 0.68 0.45-1.02 0.06 1.72 1.08-2.73 0.02 1.76 1.10-2.82 0.02
Heart disease   1.15 0.70-1.70 0.48 1.05 0.66-1.66 0.82 1.03 0.63-1.67 0.91 1.06 0.65-1.74 0.81
Smoking   1.62 1.12-2.34 0.01 1.35 0.86-2.13 0.05 1.22 0.76-1.96 0.41 1.26 0.78-2.04 0.35
Anticoagulant or thrombotics   2.26 1.53-2,26 <0.01 1.72 1.08-2.72 0.02 1.67 1.01-2.76 0.05 1.63 0.98-2.70 0.26
Total cholesterol, per mmol/L   1.07 0.91-1.26 0.42 1.01 0.81-1.01 0.43 1.01 0.83-1.23 0.93 1.05 0.86-1.28 0.27
WML*              
Confluent   6.24 3.96-9.83 <0.01 4.08 2.37-7.02 <0.01 4.87 2.78-8.52 <0.01 4.56 2.59-8.03 <0.01
Early confluent   3.92 2.47-6.22 <0.01 2.66 1.60-4.41 <0.01 2.67 1.57-4.53 <0.01 2.54 1.49-4.34 <0.01
Puctate   1.82 1.06-3.14 0.03 1.31 0.72-2.39 0.38 1.60 0.85-3.01 0.15 .1.49 0.79-2.83 0.22
Normal,ref              
p for trend     <0.01       <0.01    <0.01
Quartiles of cystatin C              
Q4(≥66.7) 168 2.19 1.40-3.40 <0.01 1.90 1.07-3.37 0.02     2.06 1.07-3.94 0.03
Q3(54.7-66.7) 173 1.57 0.92-2.46 0.10 1.31 0.45-1.28 0.35     2.20 1.18-4.09 0.01
Q2(47.2-54.7) 162 0.98 0.61-1.58 0.16 1.54 0.85-2.80 0.16     1.36 0.78-2.36 0.27
Q1(≤47.2), ref 180             
p for trend     <0.01    <0.01       <0.01
Quartiles of Alb/Cr*,              
Q4(≥100.8) 160 1.52 0.87-2.66 0.14     1.61 0.88-2.95 0.13 1.34 0.71-1.43 0.36
Q3(24.0-.100.8) 136 1.20 0.70-2.06 0.51     1.32 0.75-2.29 0.33 1.28 0.73-1.48 0.38
Q2(11.0-24.0) 217 0.97 0.52-1.80 0.91     1.09 0.59-2.03 0.78 0.86 0.53-1.61 0.76
Q1(≤11.0),ref 170             
p for trend     0.10       0.16    0.20
  1. *WML;white matter lesions, Alb/Cr; albumin/creatinine ratio.
  2. †Model 1: quartiles of microalbumin/creatinine and cystatin C were analyzed separately in the individual ordinal logistic regression model.
  3. ‡Model 2: quartiles of microalbumin/creatinine and cystatin C were analyzed together in the same logistic regression model.
  4. Model 1 and model 2 were adjusted for covariates; age, sex, total cholesterol, diabetes, hypertension, dyslipidemia, previous heart disease, smoking, previous anti thrombotic or anticoagulant use, and white matter lesions.