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Table 3 Ordinal logistic regression analysis for the association of renal indicators and cerebral microbleeds

From: Cystatin C, a novel indicator of renal function, reflects severity of cerebral microbleeds

     

Model1†

  

Model2‡

     

Variables

N

Unadjusted OR

95% CI

P

Adjusted OR

95% CI

p

Adjusted OR

95% CI

p

Adjusted OR

95% CI

p

Age, per year

 

1.02

1.01-1.04

<0.01

1.02

1.02-1.04

<0.01

1.02

1.00-1.04

0.06

1.01

1.01-1.05

0.01

Male

 

1.08

0.65-1.31

0.66

1.36

0.73-1.36

0.76

1.39

0.87-2.22

0.17

1.31

0.86-2.12

0.27

Hypertension

 

1.74

1.24-2.44

<0.01

1.43

1.05-2.18

0.03

1.77

1.14-2.78

<0.01

1.83

1.17-2.86

<0.01

Diabetes

 

1.19

0.82-1.72

0.36

0.85

0.57-1.28

0.45

1.04

0.64-1.68

0.88

1.10

0.68-1.79

0.70

Dyslipidemia

 

1.35

0.51-1.08

0.12

0.68

0.45-1.02

0.06

1.72

1.08-2.73

0.02

1.76

1.10-2.82

0.02

Heart disease

 

1.15

0.70-1.70

0.48

1.05

0.66-1.66

0.82

1.03

0.63-1.67

0.91

1.06

0.65-1.74

0.81

Smoking

 

1.62

1.12-2.34

0.01

1.35

0.86-2.13

0.05

1.22

0.76-1.96

0.41

1.26

0.78-2.04

0.35

Anticoagulant or thrombotics

 

2.26

1.53-2,26

<0.01

1.72

1.08-2.72

0.02

1.67

1.01-2.76

0.05

1.63

0.98-2.70

0.26

Total cholesterol, per mmol/L

 

1.07

0.91-1.26

0.42

1.01

0.81-1.01

0.43

1.01

0.83-1.23

0.93

1.05

0.86-1.28

0.27

WML*

             

Confluent

 

6.24

3.96-9.83

<0.01

4.08

2.37-7.02

<0.01

4.87

2.78-8.52

<0.01

4.56

2.59-8.03

<0.01

Early confluent

 

3.92

2.47-6.22

<0.01

2.66

1.60-4.41

<0.01

2.67

1.57-4.53

<0.01

2.54

1.49-4.34

<0.01

Puctate

 

1.82

1.06-3.14

0.03

1.31

0.72-2.39

0.38

1.60

0.85-3.01

0.15

.1.49

0.79-2.83

0.22

Normal,ref

             

p for trend

   

<0.01

     

<0.01

  

<0.01

Quartiles of cystatin C

             

Q4(≥66.7)

168

2.19

1.40-3.40

<0.01

1.90

1.07-3.37

0.02

   

2.06

1.07-3.94

0.03

Q3(54.7-66.7)

173

1.57

0.92-2.46

0.10

1.31

0.45-1.28

0.35

   

2.20

1.18-4.09

0.01

Q2(47.2-54.7)

162

0.98

0.61-1.58

0.16

1.54

0.85-2.80

0.16

   

1.36

0.78-2.36

0.27

Q1(≤47.2), ref

180

            

p for trend

   

<0.01

  

<0.01

     

<0.01

Quartiles of Alb/Cr*,

             

Q4(≥100.8)

160

1.52

0.87-2.66

0.14

   

1.61

0.88-2.95

0.13

1.34

0.71-1.43

0.36

Q3(24.0-.100.8)

136

1.20

0.70-2.06

0.51

   

1.32

0.75-2.29

0.33

1.28

0.73-1.48

0.38

Q2(11.0-24.0)

217

0.97

0.52-1.80

0.91

   

1.09

0.59-2.03

0.78

0.86

0.53-1.61

0.76

Q1(≤11.0),ref

170

            

p for trend

   

0.10

     

0.16

  

0.20

  1. *WML;white matter lesions, Alb/Cr; albumin/creatinine ratio.
  2. †Model 1: quartiles of microalbumin/creatinine and cystatin C were analyzed separately in the individual ordinal logistic regression model.
  3. ‡Model 2: quartiles of microalbumin/creatinine and cystatin C were analyzed together in the same logistic regression model.
  4. Model 1 and model 2 were adjusted for covariates; age, sex, total cholesterol, diabetes, hypertension, dyslipidemia, previous heart disease, smoking, previous anti thrombotic or anticoagulant use, and white matter lesions.