First author
|
Year
|
Country
|
Ethnicity
|
Genotyping method
|
AD diagnostic
|
Control sources
|
HWE
|
Case (EOAD/LOAD)
|
Control
|
---|
Sun
|
2005
|
China
|
Asian
|
PCR-RFLP
|
NINCDS-ADRDA and DSM-IV
|
PB
|
0.552
|
165
|
174
|
Li
|
2004
|
China
|
Asian
|
PCR-RFLP
|
NINCDS-ADRDA
|
PB
|
0.484
|
156(42/114)
|
183
|
Jhoo
|
2005
|
Korea
|
Asian
|
DASH
|
NINCDS-ADRDA
|
PB
|
0.701
|
107(36/71)
|
216
|
Matsui
|
2001
|
Japan
|
Asian
|
PCR-RFLP
|
NINCDS-ADRDA
|
PB
|
0.000
|
275
|
479
|
| |
USA
|
Caucasian
|
PCR-RFLP
|
autopsy-confirmed
|
PB
|
0.191
|
69
|
50
|
Papassotiropoulos
|
1999
|
Germany
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
PB
|
0.21
|
102
|
351
|
McIlroy
|
1999
|
Ireland
|
Caucasian
|
PCR-RFLP
|
DSM IV and NINCDS-ADRDA
|
PB
|
0.367
|
183
|
187
|
Papassotiropoulos
|
2000(b)
|
Germany
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
HB
|
0.485
|
127
|
184
|
Bhojak
|
2000
|
USA
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
HB
|
0.084
|
531
|
316
|
Crawford
|
2000
|
USA
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
HB
|
0.319
|
210
|
120
|
| |
Spain
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
HB
|
0.101
|
79
|
112
|
Menzer
|
2001
|
Germany, Switzerland, Italy
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
HB and PB
|
0.988
|
324
|
302
|
Bertram
|
2001
|
USA
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
HB
|
0.373
|
200
|
182
|
Emahazion
|
2001
|
Scotland
|
Caucasian
|
DASH
|
DSM-IV
|
Not clarified.
|
0.329
|
120
|
149
|
Bagnoli
|
2002
|
Italy
|
Caucasian
|
PCR-RFLP
|
DSM-IV
|
PB
|
0.616
|
197(33/33)
|
126
|
Mateo
|
2002
|
Spain
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
HB
|
0.008
|
311(126/185)
|
346
|
Styczynska
|
2003
|
Polish
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
HB
|
0.637
|
100
|
100
|
Ingegni
|
2003
|
Italy
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
HB
|
0.914
|
142
|
120
|
Beryer
|
2005
|
Spain
|
Caucasian
|
PCR-RFLP
|
DSM-IV and NINCDS-ADRDA
|
Not clarified.
|
0.871
|
205
|
181
|
Blomqvist2
|
2006
|
Switzerland
|
Caucasian
|
DASH
|
NINCDS-ADRDA
|
HB and PB
|
0.372
|
385
|
173
|
Mariani
|
2006
|
Italy
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
PB
|
0.355
|
100
|
136
|
Davidson
|
2006
|
UK
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
HB
|
0.168
|
560(317/243)
|
767
|
Capurso
|
2008
|
Italy
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
PB
|
0.205
|
242(57/185)
|
421
|
Albayrak
|
2010
|
Germany
|
Caucasian
|
PCR-RFLP
|
NINCDS-ADRDA
|
HB
|
0.143
|
219
|
215
|
M. Schuur
|
2011
|
Netherland
|
Caucasian
|
Taqman assay
|
NINCDS-ADRDA
|
PB
|
0.631
|
493
|
5619
|
-
PCR–RFLP, Polymerase chain reaction-restriction fragment length polymorphism; DASH, dynamic allele specific hybridization; PB, Population–based; HB, Hospital–based; HWE, hardy-Weinberg equilibrium; EOAD, early-onset AD; LOAD, late-onset AD.