Lack of association between cathepsin D C224T polymorphism and Alzheimer’s disease risk: an update meta-analysis

Mo, Cuiju; Peng, Qiliu; Sui, Jingzhe; Wang, Jian; Deng, Yan; Xie, Li; Li, Taijie; He, Yu; Qin, Xue; Li, Shan

doi:10.1186/1471-2377-14-13

BMC Neurology

Table 1 The baseline data of all including study

From: Lack of association between cathepsin D C224T polymorphism and Alzheimer’s disease risk: an update meta-analysis

First author	Year	Country	Ethnicity	Genotyping method	AD diagnostic	Control sources	HWE	Case (EOAD/LOAD)	Control
Sun	2005	China	Asian	PCR-RFLP	NINCDS-ADRDA and DSM-IV	PB	0.552	165	174
Li	2004	China	Asian	PCR-RFLP	NINCDS-ADRDA	PB	0.484	156(42/114)	183
Jhoo	2005	Korea	Asian	DASH	NINCDS-ADRDA	PB	0.701	107(36/71)	216
Matsui	2001	Japan	Asian	PCR-RFLP	NINCDS-ADRDA	PB	0.000	275	479
		USA	Caucasian	PCR-RFLP	autopsy-confirmed	PB	0.191	69	50
Papassotiropoulos	1999	Germany	Caucasian	PCR-RFLP	NINCDS-ADRDA	PB	0.21	102	351
McIlroy	1999	Ireland	Caucasian	PCR-RFLP	DSM IV and NINCDS-ADRDA	PB	0.367	183	187
Papassotiropoulos	2000(b)	Germany	Caucasian	PCR-RFLP	NINCDS-ADRDA	HB	0.485	127	184
Bhojak	2000	USA	Caucasian	PCR-RFLP	NINCDS-ADRDA	HB	0.084	531	316
Crawford	2000	USA	Caucasian	PCR-RFLP	NINCDS-ADRDA	HB	0.319	210	120
		Spain	Caucasian	PCR-RFLP	NINCDS-ADRDA	HB	0.101	79	112
Menzer	2001	Germany, Switzerland, Italy	Caucasian	PCR-RFLP	NINCDS-ADRDA	HB and PB	0.988	324	302
Bertram	2001	USA	Caucasian	PCR-RFLP	NINCDS-ADRDA	HB	0.373	200	182
Emahazion	2001	Scotland	Caucasian	DASH	DSM-IV	Not clarified.	0.329	120	149
Bagnoli	2002	Italy	Caucasian	PCR-RFLP	DSM-IV	PB	0.616	197(33/33)	126
Mateo	2002	Spain	Caucasian	PCR-RFLP	NINCDS-ADRDA	HB	0.008	311(126/185)	346
Styczynska	2003	Polish	Caucasian	PCR-RFLP	NINCDS-ADRDA	HB	0.637	100	100
Ingegni	2003	Italy	Caucasian	PCR-RFLP	NINCDS-ADRDA	HB	0.914	142	120
Beryer	2005	Spain	Caucasian	PCR-RFLP	DSM-IV and NINCDS-ADRDA	Not clarified.	0.871	205	181
Blomqvist2	2006	Switzerland	Caucasian	DASH	NINCDS-ADRDA	HB and PB	0.372	385	173
Mariani	2006	Italy	Caucasian	PCR-RFLP	NINCDS-ADRDA	PB	0.355	100	136
Davidson	2006	UK	Caucasian	PCR-RFLP	NINCDS-ADRDA	HB	0.168	560(317/243)	767
Capurso	2008	Italy	Caucasian	PCR-RFLP	NINCDS-ADRDA	PB	0.205	242(57/185)	421
Albayrak	2010	Germany	Caucasian	PCR-RFLP	NINCDS-ADRDA	HB	0.143	219	215
M. Schuur	2011	Netherland	Caucasian	Taqman assay	NINCDS-ADRDA	PB	0.631	493	5619

PCR–RFLP, Polymerase chain reaction-restriction fragment length polymorphism; DASH, dynamic allele specific hybridization; PB, Population–based; HB, Hospital–based; HWE, hardy-Weinberg equilibrium; EOAD, early-onset AD; LOAD, late-onset AD.

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ISSN: 1471-2377

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