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Table 1 The baseline data of all including study

From: Lack of association between cathepsin D C224T polymorphism and Alzheimer’s disease risk: an update meta-analysis

First author Year Country Ethnicity Genotyping method AD diagnostic Control sources HWE Case (EOAD/LOAD) Control
Sun 2005 China Asian PCR-RFLP NINCDS-ADRDA and DSM-IV PB 0.552 165 174
Li 2004 China Asian PCR-RFLP NINCDS-ADRDA PB 0.484 156(42/114) 183
Jhoo 2005 Korea Asian DASH NINCDS-ADRDA PB 0.701 107(36/71) 216
Matsui 2001 Japan Asian PCR-RFLP NINCDS-ADRDA PB 0.000 275 479
   USA Caucasian PCR-RFLP autopsy-confirmed PB 0.191 69 50
Papassotiropoulos 1999 Germany Caucasian PCR-RFLP NINCDS-ADRDA PB 0.21 102 351
McIlroy 1999 Ireland Caucasian PCR-RFLP DSM IV and NINCDS-ADRDA PB 0.367 183 187
Papassotiropoulos 2000(b) Germany Caucasian PCR-RFLP NINCDS-ADRDA HB 0.485 127 184
Bhojak 2000 USA Caucasian PCR-RFLP NINCDS-ADRDA HB 0.084 531 316
Crawford 2000 USA Caucasian PCR-RFLP NINCDS-ADRDA HB 0.319 210 120
   Spain Caucasian PCR-RFLP NINCDS-ADRDA HB 0.101 79 112
Menzer 2001 Germany, Switzerland, Italy Caucasian PCR-RFLP NINCDS-ADRDA HB and PB 0.988 324 302
Bertram 2001 USA Caucasian PCR-RFLP NINCDS-ADRDA HB 0.373 200 182
Emahazion 2001 Scotland Caucasian DASH DSM-IV Not clarified. 0.329 120 149
Bagnoli 2002 Italy Caucasian PCR-RFLP DSM-IV PB 0.616 197(33/33) 126
Mateo 2002 Spain Caucasian PCR-RFLP NINCDS-ADRDA HB 0.008 311(126/185) 346
Styczynska 2003 Polish Caucasian PCR-RFLP NINCDS-ADRDA HB 0.637 100 100
Ingegni 2003 Italy Caucasian PCR-RFLP NINCDS-ADRDA HB 0.914 142 120
Beryer 2005 Spain Caucasian PCR-RFLP DSM-IV and NINCDS-ADRDA Not clarified. 0.871 205 181
Blomqvist2 2006 Switzerland Caucasian DASH NINCDS-ADRDA HB and PB 0.372 385 173
Mariani 2006 Italy Caucasian PCR-RFLP NINCDS-ADRDA PB 0.355 100 136
Davidson 2006 UK Caucasian PCR-RFLP NINCDS-ADRDA HB 0.168 560(317/243) 767
Capurso 2008 Italy Caucasian PCR-RFLP NINCDS-ADRDA PB 0.205 242(57/185) 421
Albayrak 2010 Germany Caucasian PCR-RFLP NINCDS-ADRDA HB 0.143 219 215
M. Schuur 2011 Netherland Caucasian Taqman assay NINCDS-ADRDA PB 0.631 493 5619
  1. PCR–RFLP, Polymerase chain reaction-restriction fragment length polymorphism; DASH, dynamic allele specific hybridization; PB, Population–based; HB, Hospital–based; HWE, hardy-Weinberg equilibrium; EOAD, early-onset AD; LOAD, late-onset AD.