Table 3 Meta-analysis the association of CTSD C224T polymorphism with APOEϵ4 carrier in AD
Comparison | Population | No. of studies | Test of association | Mode | Test of heterogeneity | ||||
|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | P Value | x 2 | PQ Value | I2 | ||||
APOEϵ4 noncarriers | |||||||||
CT + TT vs. CC | Overall | 10 | 1.139 | 0.844–1.539 | 0.395 | R | 19.28 | 0.023 | 53.3 |
Asian | 3 | 0.73 | 0.390–1.365 | 0.324 | F | 5.81 | 0.055 | 65.5 | |
Caucasian | 7 | 1.212 | 0.998–1.472 | 0.052 | F | 11.86 | 0.065 | 49.4 | |
APOEϵ4 carriers | |||||||||
CT + TT vs. CC | Overall | 10 | 1.267 | 0.979–1.641 | 0.072 | F | 10.89 | 0.283 | 17.4 |
Asian | 3 | 1.273 | 0.511–3.184 | 0.604 | F | 0.01 | 0.995 | 0.0 | |
T carriers | Caucasian | 7 | 1.267 | 0.979–1.641 | 0.085 | F | 10.88 | 0.092 | 44.9 |
APOEϵ4(+) vs. APOEϵ4(–) | Overall | 10 | 4.532 | 2.755–7.455 | 0.000 | R | 18.16 | 0.033 | 50.4 |
Asian | 3 | 7.913 | 2.632–23.785 | 0.000 | F | 0.20 | 0.904 | 0.0 | |
Caucasian | 7 | 4.134 | 2.338–7.310 | 0.000 | R | 15.58 | 0.016 | 61.5 | |
T noncarriers | |||||||||
APOEϵ4(+) vs. APOEϵ4(–) | Overall | 10 | 4.193 | 3.096–5.679 | 0.000 | R | 43.54 | 0.000 | 79.3 |
Asian | 3 | 4.217 | 2.333–7.620 | 0.000 | R | 6.88 | 0.032 | 70.9 | |
Caucasian | 7 | 4.195 | 2.888–6.093 | 0.000 | R | 35.89 | 0.000 | 83.3 | |