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Table 3 Meta-analysis the association of CTSD C224T polymorphism with APOEϵ4 carrier in AD

From: Lack of association between cathepsin D C224T polymorphism and Alzheimer’s disease risk: an update meta-analysis

Comparison Population No. of studies Test of association Mode Test of heterogeneity
    OR 95% CI P Value   x 2 PQ Value I2
APOEϵ4 noncarriers
CT + TT vs. CC Overall 10 1.139 0.844–1.539 0.395 R 19.28 0.023 53.3
  Asian 3 0.73 0.390–1.365 0.324 F 5.81 0.055 65.5
  Caucasian 7 1.212 0.998–1.472 0.052 F 11.86 0.065 49.4
APOEϵ4 carriers
CT + TT vs. CC Overall 10 1.267 0.979–1.641 0.072 F 10.89 0.283 17.4
  Asian 3 1.273 0.511–3.184 0.604 F 0.01 0.995 0.0
T carriers Caucasian 7 1.267 0.979–1.641 0.085 F 10.88 0.092 44.9
APOEϵ4(+) vs. APOEϵ4(–) Overall 10 4.532 2.755–7.455 0.000 R 18.16 0.033 50.4
  Asian 3 7.913 2.632–23.785 0.000 F 0.20 0.904 0.0
  Caucasian 7 4.134 2.338–7.310 0.000 R 15.58 0.016 61.5
T noncarriers          
APOEϵ4(+) vs. APOEϵ4(–) Overall 10 4.193 3.096–5.679 0.000 R 43.54 0.000 79.3
  Asian 3 4.217 2.333–7.620 0.000 R 6.88 0.032 70.9
  Caucasian 7 4.195 2.888–6.093 0.000 R 35.89 0.000 83.3
  1. OR, odds ratio; CI, confidence intervals; R, random effects model; F, fixed effects model.