Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis

Table 5 Effect of patient, apathy, fatigue, and depression factors in the BRB-N tests

	SRT-LTS		SRT-CLTR		SRT-D		SPART		SPART-D
Explanatory variable	Standard estimate (β)	p value	Standard estimate (β)	p value	Standard estimate (β)	p value	Standard estimate (β)	p value	Standard estimate (β)	p value
Patient	−0.3135	<0.0001	−0.3465	<0.0001	−0.3189	<0.0001	−0.3591	<0.0001	−0.2706	<0.0001
Apathy	−0.1249	0.0314	−0.1154	0.0470	−0.1379	0.0191	−0.1107	n.s.	−0.1807	0.0025
Fatigue	0.1713	0.0035	0.1362	0.0199	0.1245	0.0352	0.0326	n.s.	0.060	n.s.
Depression	−0.1916	0.0028	−0.1405	0.0281	−0.1190	n.s.	−0.0803	n.s.	−0.0667	n.s.
Adjusted R-squared	0.1684		0.1668		0.1485		0.1659		0.1243
	SDMT		PASAT3		PASAT2		WLG
Explanatory variable	Standard estimate (β)	p value	Standard estimate (β)	p value	Standard estimate (β)	p value	Standard estimate (β)	p value
Patient	−0.5251	<0.0001	−0.3823	<0.0001	−0.3858	<0.0001	−0.4319	<0.0001
Apathy	−0.0764	n.s.	−0.0176	n.s.	−0.0108	n.s.	−0.1511	0.0058
Fatigue	0.1340	0.0074	0.0842	n.s.	0.0673	n.s.	0.2171	<0.0001
Depression	−0.2664	<0.0001	−0.2471	<0.0001	−0.2516	<0.0001	−0.1708	0.0046
Adjusted R-squared	0.3933		0.2221		0.2301		0.2647

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