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Table 2 Baseline scores of items assessing pain in RECOVER by severity of overall pain (Likert pain scale)

From: Rotigotine transdermal system and evaluation of pain in patients with Parkinson’s disease: a post hocanalysis of the RECOVER study

  ‘Nocturnal cramps’ (from NADCS) ‘Painful muscle cramps or spasms due to PD’ (PDQ-8 item 7) ‘Pain in arms or legs’ (PDSS-2 item 10) ‘Muscle cramps in arms or legs’ (PDSS-2 item 11) ‘Painful posturing in the morning’ (PDSS-2 item 12) ‘Suffer from pain not explained by other known conditions’ (NMSS item 29)
‘No’ pain (n = 80) (pain score 0) 0.4 ± 0.8 0.8 ± 0.9 0.5 ± 0.9 0.6 ± 1.0 0.5 ± 0.9 0.6 ± 1.8
‘Mild’ pain (n = 87) (pain score 1–3) 0.7 ± 0.9 (p = 0.020) 1.3 ± 1.0 (p < 0.001) 1.1 ± 1.1 (p <0.001) 1.0 ± 1.1 (p = 0.007) 0.7 ± 1.0 (p = 0.139) 1.1 ± 2.1 (p = 0.062)
‘Moderate-to-severe’ pain (n = 100) (pain score ≥4) 1.1 ± 1.1 (p <0.0001) 1.7 ± 1.0 (p <0.0001) 1.9 ± 1.2 (p <0.0001) 1.5 ± 1.2 (p <0.0001) 1.4 ± 1.2 (p <0.0001) 2.1 ± 3.4 (p <0.001)
  1. Data are mean ± SD. Data are presented for the FAS.
  2. P values (t-test exploratory analyses) are reported for patients with ‘Mild’ pain and patients with ‘Moderate-to-severe’ pain vs patients with ‘No’ pain at baseline (assessed by the Likert pain scale).
  3. FAS: full analysis set; NADSC: Nocturnal Akinesia, Dystonia and Cramps total score; NMSS: Non-Motor Symptoms Scale; PD: Parkinson’s disease; PDQ-8: 8-item Parkinson’s Disease Questionnaire; PDSS-2: Parkinson’s Disease Sleep Scale; RECOVER: Randomized Evaluation of the 24-hour Coverage: Efficacy of Rotigotine; SD: standard deviation.