Skip to main content

Table 2 Baseline scores of items assessing pain in RECOVER by severity of overall pain (Likert pain scale)

From: Rotigotine transdermal system and evaluation of pain in patients with Parkinson’s disease: a post hocanalysis of the RECOVER study

 

‘Nocturnal cramps’ (from NADCS)

‘Painful muscle cramps or spasms due to PD’ (PDQ-8 item 7)

‘Pain in arms or legs’ (PDSS-2 item 10)

‘Muscle cramps in arms or legs’ (PDSS-2 item 11)

‘Painful posturing in the morning’ (PDSS-2 item 12)

‘Suffer from pain not explained by other known conditions’ (NMSS item 29)

‘No’ pain (n = 80) (pain score 0)

0.4 ± 0.8

0.8 ± 0.9

0.5 ± 0.9

0.6 ± 1.0

0.5 ± 0.9

0.6 ± 1.8

‘Mild’ pain (n = 87) (pain score 1–3)

0.7 ± 0.9 (p = 0.020)

1.3 ± 1.0 (p < 0.001)

1.1 ± 1.1 (p <0.001)

1.0 ± 1.1 (p = 0.007)

0.7 ± 1.0 (p = 0.139)

1.1 ± 2.1 (p = 0.062)

‘Moderate-to-severe’ pain (n = 100) (pain score ≥4)

1.1 ± 1.1 (p <0.0001)

1.7 ± 1.0 (p <0.0001)

1.9 ± 1.2 (p <0.0001)

1.5 ± 1.2 (p <0.0001)

1.4 ± 1.2 (p <0.0001)

2.1 ± 3.4 (p <0.001)

  1. Data are mean ± SD. Data are presented for the FAS.
  2. P values (t-test exploratory analyses) are reported for patients with ‘Mild’ pain and patients with ‘Moderate-to-severe’ pain vs patients with ‘No’ pain at baseline (assessed by the Likert pain scale).
  3. FAS: full analysis set; NADSC: Nocturnal Akinesia, Dystonia and Cramps total score; NMSS: Non-Motor Symptoms Scale; PD: Parkinson’s disease; PDQ-8: 8-item Parkinson’s Disease Questionnaire; PDSS-2: Parkinson’s Disease Sleep Scale; RECOVER: Randomized Evaluation of the 24-hour Coverage: Efficacy of Rotigotine; SD: standard deviation.