Table 1 Demographic information for the 9 patients studied, EDSS scores and relapse summary information
From: Treatment of neuromyelitis optica/neuromyelitis optica spectrum disorders with methotrexate
No. | Age | Gender | Months followed | 1st attack | Type of relapses | Relapses before starting MTX | Relapse on MTX | Treatment history | Months on MTX | Initial EDSS | Final EDSS |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 40 | M | 62 | Myelitis | Myelitis | 4 | 2 | Stabilized on CTX* for 6 months, MTX** started as step down strategy, continued during last visit. | 54 | 6.5 | 1.5 |
2 | 71 | F | 13 | Optic Neuritis | Optic Neuritis and Myelitis | 10 | 0 | MTX started initially, continued during last visit. | 11 | 5.5 | 3 |
3 | 62 | F | 146 | Myelitis | Myelitis | 5 | 1 | MTX started initially, changed to MMF^^ briefly but due to S/E again started on MTX. | 24 | 6.5 | 6.5 |
4 | 38 | F | 143 | Myelitis | Optic Neuritis and Myelitis | 7 | 0 | Stabilized on CTX for 6 months, MTX started as step down strategy, continued during last visit. | 60 | 4 | 4 |
5 | 46 | F | 114 | Optic Neuritis | Optic Neuritis and Myelitis | 8 | 2 | Initially on AZA*** then following relapses MTX started, continued during last visit. | 29 | 4 | 4 |
6 | 74 | F | 62 | Myelitis | Myelitis | 4 | 2 | MTX started initially, continued during last visit. | 52 | 4.5 | 5.5 |
7 | 54 | F | 85 | Myelitis | Optic Neuritis and Myelitis | 4 | 3 | Stabilized on CTX for 6 months. MTX started as step down strategy, changed MTX to MMF due to increasing relapses and later to RTX^^^. | 24 | 2 | 4.5 |
8 | 57 | M | 59 | Myelitis | Myelitis | 2 | 3 | MTX started initially, MTX changed to MMF following continuing relapses and later to RTX. | 7 | 3.5 | 5.5 |
9 | 52 | F | 62 | Myelitis | Optic Neuritis and Myelitis | 3 | 4 | MTX started initially, RTX following continued relapses. | 52 | 2.5 | 2.5 |