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Table 2 Demographic and clinical characteristics of ET-PD patients in comparison to ET-only, PD-only patients and controls

From: Ultrasonographic (TCS) and clinical findings in overlapping phenotype of essential tremor and Parkinson’s disease (ET-PD)

Demographic and clinical characteristics Patients (n = 272) Pvalue* Controls (n = 101) Pvalue#
ET-PD (n = 15) ET-only (n = 116) PD-only (n = 141)
Age, y 69 ± 9.6 63.9 ± 14.4 64.4 ± 11.2 NS 61.7 ± 12.4 NS
Gender (male) 6 (40) 39 (33.6) 75 (53.2) 0.007 56 (55.4) 0.004
Sympt. duration y 6 (3-15) 5 (1-10) 3 (1-6) 0.003a N/A N/A
Family history + 8 (53.3) 35 (31.3) 23 (17) 0.005 4 (4.3) <0.001
Toxic exposure 3 (20) 19 (16.4) 23 (16.3) NS 16 (15.8) NS
Living in rural 4 (26.7) 19 (16.4) 29 (20.6) NS 16 (15.8) NS
Cogwheel sign 4 (26.7) 3 (2.6) 129 (91.5) <0.001 0 (0) <0.001
Pyramidal signs 2 (13.3) 3 (2.6) 19 (13.5) 0.009 10 (9.9) 0.025
H&Y stage 2.6 ± 0.8 N/A 1.8 ± 0.8 0.012 N/A N/A
UPDRS part I 1 (0-1) 1 (0-3) 3 (1-4) NS N/A N/A
UPDRS part II 5 (4-6) 13 (12-13) 11 (7-16) NS N/A N/A
UPDRS part III 5 (3-6) 4 (1-6) 14 (9-20) 0.021b N/A N/A
HAD-Anxiety 1 (1-8) 6 (2-10) 8 (5-11) NS 5 (3-8) NS
HAD-Depression 4 (4-7) 4 (2-6) 6 (4-9) NS 3 (1-7) NS
SF36-PF 53.3 ± 17.6 52.3 ± 31.8 45.9 ± 25.3 NS 70 ± 24.2 0.001c
SF36-RLPF 16.7 ± 28.9 33.1 ± 29 33.3 ± 27 NS 50.2 ± 29.4 0.020d
SF36-RLEF 33.3 ± 57.7 51.4 ± 30 40.8 ± 34.2 NS 59 ± 32.2 NSe
SF36-EF 43.3 ± 10.4 43.8 ± 24.8 44.5 ± 19.4 NS 58.8 ± 17.1 0.007f
SF36-EW 66.7 ± 38.9 52.5 ± 26 53.7 ± 19.3 NS 64.7 ± 15.8 NSg
SF36-SF 58.3 ± 19.1 57.3 ± 31.5 53.8 ± 24.9 NS 75.7 ± 46.7 0.050h
SF36-P 66.7 ± 18.8 65.7 ± 26.7 49.5 ± 30.7 NS 61.7 ± 28.2 NS
SF36-GH 28.3 ± 2.9 35 ± 19.4 31.1 ± 16.9 NS 49.1 ± 18.5 <0.001i
  1. Values are presented as mean ± SD or median with IQR, and numbers (percentages). *- p values were counted comparing 3 groups of patients, #- p values were counted comparing 4 groups of subjects where available.
  2. The post hoc multiple comparisons between the groups by Tukey HSD and LSD tests revealed significant differences:
  3. a-ET-PD vs. PD-only p = 0.001, 95% CI 2.8-13.1, ET-only vs. PD-only p = 0.002, 95% CI 1.12-5.87; b-LSD test only PD vs. ET-only p = 0.009, 95% CI 2.32-15.61; ET-PD vs. ET-only p = 0.008, 95% CI 4.86-31.08; c-PD-only vs. control group p = 0.001, 95% CI 8.37-39.88; d-PD-only vs. control group p = 0.05, 95% CI 0.01-33.83; e-LSD test only, PD-only vs. control group p = 0.018, 95% CI 3.16-33.19; f-PD-only vs. control group p = 0.011, 95% CI 2.48-26.16; ET-only vs. control group p = 0.024, 95% CI 1.46-28.67; g-LSD test only, PD-only vs. controls p = 0.021, 95% CI 1.66-20.19; ET-only vs. controls p = 0.026, 95% CI 1.46-22.76; h-PD-only vs. control group p = 0.039, 95% CI 0.77-43.1; i-PD-only vs. controls p < 0.001, 95% CI 7.24-28.62; ET-only vs. controls p = 0.018, 95% CI 1.77-26.34; LSD test only, PD-only vs. ET-only p = 0.031, 95% CI 1.52-30.94.