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Baclofen
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No effect [37].
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Dantrolene
|
No effect [38].
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|
Pregabalin
|
Consuming with food decreased Cmaxby 25–30% and delayedtmaxby ≈3h [39].
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Tizanidine
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Simultaneous food intake with a tizanidinecapsule reduced Cmaxand AUCo–t by <20% and extendedtmax from 0.75 h to 1.5 h.
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Extent of absorption is increased ≤20% relative to administration of the tizanidine capsule under fasted conditions.
|
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In contrast,simultaneous food consumption with a tizanidinetablet increased Cmax and AUCo–t by22.6% and 45.2%, respectively [40].
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The dosage forms of the tablet and capsule were not bioequivalent if administered with food.
|
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Food increasedthe tmax and the extent of absorption for the tablet and capsule. However, the Cmaxvalues of tizanidine achieved if administered with food were increased by 30% for the tablet but decreased by 20% for the capsule. Under fed conditions, the capsule was ≈80% bioavailable relative to the tablet.
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Using tizanidine together with caffeine is, in general, not recommended. Combining these medications may significantly increase the blood levels and effects of tizanidine.
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Gabapentin
|
High-protein food increased the AUC and Cmaxby 26% and 32%, respectively [41].
|
Take extended release tablet with evening meal. Swallow whole; do not chew, crush, or split.
|
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No significant effects on the rate or extent of absorption of the immediate-release tablet were noted. The rate and extent of absorption of the extended-release tablet was increased.
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Carbamazepine
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Serum levels of carbamazepine may be increased if taken with food and/or grapefruit juice.
|
Extended-release tablets should be administered with meals; swallow whole, do not crush or chew.
|
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SSRIs
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Paroxetine: peak concentration is increased, but bioavailability is not significantly altered by food.
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Sertraline: average peak serum levels may be increased if taken with food.
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