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Azathioprine
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Take after meals or in divided doses for reducing the risk of stomach upset.
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Cyclophosphamide
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On an empty stomach with a glass of water or juice or with food.
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Tablets are not scored and should not be cut or crushed. Do not take tablets at bedtime to minimize the risk of bladder irritation.
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Methotrexate
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Peak serum levels of methotrexate may be decreased if taken with food. Milk-rich foods may decrease methotrexate absorption.
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On empty stomach with plenty of water.
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Limit or avoid caffeine intake. Avoid drinks (e.g., coffee, tea, cola), foods (e.g., chocolate) or diet pills that contain caffeine.
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